Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | carbonic anhydrase | 0.1464 | 0.462 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0223 | 0.0494 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0257 | 0.0609 | 0.1835 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.3084 | 1 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1577 | 0.4995 | 0.9536 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.106 | 0.3276 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3084 | 1 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1577 | 0.4995 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0077 | 0.001 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1651 | 0.5238 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0987 | 0.3033 | 0.9256 |
Loa Loa (eye worm) | hypothetical protein | 0.2753 | 0.8901 | 0.7956 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0077 | 0.001 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.3084 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.3084 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3084 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3084 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1651 | 0.5238 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1651 | 0.5238 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.3084 | 1 | 1 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0257 | 0.0609 | 0.1219 |
Schistosoma mansoni | carbonic anhydrase | 0.1577 | 0.4995 | 0.0698 |
Echinococcus granulosus | carbonic anhydrase II | 0.3084 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1577 | 0.4995 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3084 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1464 | 0.462 | 0.4614 |
Onchocerca volvulus | 0.0223 | 0.0494 | 1 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.3084 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1464 | 0.462 | 0.4614 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0848 | 0.2571 | 0.7843 |
Echinococcus granulosus | carbonic anhydrase | 0.1464 | 0.462 | 0.4614 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.3084 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1464 | 0.462 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.