Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.0861 | 0.3793 | 0.4143 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.197 | 0.9134 | 0.8606 |
Plasmodium falciparum | carbonic anhydrase | 0.0861 | 0.3793 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0848 | 0.3728 | 0.7843 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0987 | 0.4397 | 0.9256 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.197 | 0.9134 | 1 |
Onchocerca volvulus | 0.0223 | 0.0717 | 1 | |
Echinococcus granulosus | carbonic anhydrase | 0.0861 | 0.3793 | 0.4143 |
Leishmania major | carbonic anhydrase-like protein | 0.197 | 0.9134 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1577 | 0.7242 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.197 | 0.9134 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1577 | 0.7242 | 0.6458 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0257 | 0.0883 | 0.1835 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.197 | 0.9134 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1651 | 0.7595 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1651 | 0.7595 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.197 | 0.9134 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.197 | 0.9134 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.197 | 0.9134 | 0.8606 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.197 | 0.9134 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0077 | 0.0014 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.197 | 0.9134 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0861 | 0.3793 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1651 | 0.7595 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0077 | 0.0014 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1577 | 0.7242 | 0.9536 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.197 | 0.9134 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0861 | 0.3793 | 0.4143 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1577 | 0.7242 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.197 | 0.9134 | 0.5 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0257 | 0.0883 | 0.1219 |
Onchocerca volvulus | Putative sulfate transporter | 0.0223 | 0.0717 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.106 | 0.475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILS (functional) | = 235 % | Compound was evaluated for antitumor activity against L1210 leukemia in mice and percent increase in life span was determined. | ChEMBL. | 6699882 |
ILS (functional) | = 235 % | Compound was evaluated for antitumor activity against L1210 leukemia in mice and percent increase in life span was determined. | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000000001 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000000001 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000000016 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000000016 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.00007 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.00007 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.00022 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.00022 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (functional) | = 0.003 % | Compound was evaluated for 50% inhibition of the growth of Lactobacillus casei ATCC7469 strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | = 0.17 % | Compound was evaluated for 50% inhibition of the growth of Streptococcus faecium ATCC8043 strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | = 11 % | Compound was evaluated for 50% inhibition of the growth of Pediococcus cerevisiae at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | = 1300 % | Compound was evaluated for 50% inhibition of the growth of Streptococcus faecium MTX resistant strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | > 2000 % | Compound was evaluated for 50% inhibition of the growth of Lactobacillus casei MTX resistant strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
LD10 (ADMET) | = 1.5 mg kg-1 | Compound was evaluated for antitumor activity against L1210 leukemia in mice and LD10 was determined 24 hour after subcutaneous administration of the compound in 10 E 6 cells implanted intraperitoneally. | ChEMBL. | 6699882 |
LD10 (ADMET) | = 1.5 mg kg-1 | Compound was evaluated for antitumor activity against L1210 leukemia in mice and LD10 was determined 24 hour after subcutaneous administration of the compound in 10 E 6 cells implanted intraperitoneally. | ChEMBL. | 6699882 |
MST (functional) | = 23.8 day | Compound was evaluated for antitumor activity against L1210 leukemia in mice and median survival time was determined at ten animals per run. | ChEMBL. | 6699882 |
MST (functional) | = 23.8 day | Compound was evaluated for antitumor activity against L1210 leukemia in mice and median survival time was determined at ten animals per run. | ChEMBL. | 6699882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.