Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative sulfate transporter | 0.0208 | 0.0673 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0993 | 0.4462 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1478 | 0.6804 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.214 | 1 | 0.5 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0241 | 0.083 | 0.1219 |
Toxoplasma gondii | hypothetical protein | 0.0878 | 0.3905 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1547 | 0.7135 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1478 | 0.6804 | 0.9536 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0072 | 0.0013 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.214 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0878 | 0.3905 | 0.3897 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0072 | 0.0013 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2085 | 0.9737 | 0.9568 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.214 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.214 | 1 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.214 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.214 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1478 | 0.6804 | 0.4757 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0241 | 0.083 | 0.1835 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1547 | 0.7135 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.214 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1547 | 0.7135 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.214 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0878 | 0.3905 | 0.3897 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1478 | 0.6804 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.214 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0878 | 0.3905 | 0.3897 |
Echinococcus multilocularis | carbonic anhydrase II | 0.214 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0794 | 0.3502 | 0.7843 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0925 | 0.4131 | 0.9256 |
Plasmodium falciparum | carbonic anhydrase | 0.0878 | 0.3905 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.214 | 1 | 1 |
Onchocerca volvulus | 0.0208 | 0.0673 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 150 nM | Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose. | ChEMBL. | 7562911 |
IC50 (functional) | = 150 nM | Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose. | ChEMBL. | 7562911 |
Inhibition (functional) | 0 % | In vitro inhibition of phospho-p185erbB-2 expression in human breast cancer cells(SK-BR-3 cells) at at 100 mg/kg dose (inactive) | ChEMBL. | 7562911 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7562911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.