Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene monooxygenase, putative | 0.1898 | 0.5 | 0.5 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.1898 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.1898 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.008 ug ml-1 | In vitro antibacterial activity against Streptococcus pneumoniae ATCC 6303 (an erythromycin-susceptiblestrain) | ChEMBL. | 15203167 |
MIC (functional) | = 0.06 ug ml-1 | In vitro antibacterial activity against Streptococcus pneumoniae 5649 (efflux-resistantstrain bearing a mef (E) gene) | ChEMBL. | 15203167 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus NCTC 10649 (erythromycin-susceptiblestrain) | ChEMBL. | 15203167 |
MIC (functional) | = 4 ug ml-1 | In vitro antibacterial activity against Streptococcus pneumoniae 5979 (MLSB resistant stain bearing an erm (B) gene) | ChEMBL. | 15203167 |
MIC (functional) | = 8 ug ml-1 | In vitro antibacterial activity against Haemophilus influenzae GYR1435 (fully susceptible strain) | ChEMBL. | 15203167 |
MIC (functional) | = 64 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus 1775 (methicillin-resistant strain(MRSA)) | ChEMBL. | 15203167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.