Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1523 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 12 nM | Effective concentration of the compound binding towards TRalpha in E25B2 cells (agonistic activity) | ChEMBL. | 12565933 |
EC50 (binding) | = 12 nM | Effective concentration of the compound binding towards TRalpha in E25B2 cells (agonistic activity) | ChEMBL. | 12565933 |
IC50 (binding) | = 9.78 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
IC50 (binding) | = 9.95 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Ki (binding) | = 0.04 nM | Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptor | ChEMBL. | 12565933 |
Ki (binding) | = 0.04 nM | Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptor | ChEMBL. | 12565933 |
Ki (binding) | = 0.06 nM | Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptor | ChEMBL. | 12565933 |
Ki (binding) | = 0.06 nM | Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptor | ChEMBL. | 12565933 |
Log IC50 (binding) | = 9.78 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Log IC50 (binding) | = 9.95 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Ratio (binding) | = 15 | Selectivity of the compound measured as ratio of TRalpha Ki/TRbeta Ki | ChEMBL. | 12565933 |
Ratio (binding) | = 58.2 | Selectivity of the compound measured as ratio of TRalpha Ki/TRbeta Ki | ChEMBL. | 12565933 |
Ratio (binding) | = 15 | Selectivity of the compound measured as ratio of TRalpha Ki/TRbeta Ki | ChEMBL. | 12565933 |
Ratio (binding) | = 58.2 | Selectivity of the compound measured as ratio of TRalpha Ki/TRbeta Ki | ChEMBL. | 12565933 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.