Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | squalene monooxygenase, putative | 0.1702 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.1702 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.1702 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED90 (functional) | > 2.5 mg kg-1 | Antiparasitic activity against sheep parasite Trichostrongylus colubriformis | ChEMBL. | 2913297 |
ED90 (functional) | > 1 p.p.m. | Antiparasitic activity against southern army worm Spodoptera eridania | ChEMBL. | 2913297 |
ED90 (functional) | > 6.25 p.p.m. | Antiparasitic activity against two-spotted spider mite Tetranychus urticae on bean plants | ChEMBL. | 2913297 |
Ki (binding) | = 0.8 nM | Displacement of ivermectin from avermectin receptor of C. elegans | ChEMBL. | 2913297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.