Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0581 | 0.7622 | 0.7622 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0183 | 0.2316 | 0.2316 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0405 | 0.0405 |
Onchocerca volvulus | Apolipophorins homolog | 0.0431 | 0.5622 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.004 | 0.0405 | 0.0405 |
Schistosoma mansoni | atypical protein kinase C | 0.0015 | 0.0081 | 0.0081 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0581 | 0.7622 | 0.7622 |
Loa Loa (eye worm) | hypothetical protein | 0.076 | 1 | 1 |
Brugia malayi | protein kinase C II. | 0.0016 | 0.0097 | 0.0128 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0146 | 0.1825 | 0.3215 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.004 | 0.0405 | 0.0405 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0624 | 0.0624 |
Brugia malayi | Protein kinase domain containing protein | 0.0183 | 0.2316 | 0.3038 |
Echinococcus granulosus | protein kinase c iota type | 0.0015 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0016 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0183 | 0.2316 | 0.2316 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Brugia malayi | Protein kinase c protein 2 | 0.0048 | 0.0512 | 0.0672 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0016 | 0.0097 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.076 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Plasmodium vivax | topoisomerase I, putative | 0.0581 | 0.7622 | 0.5 |
Echinococcus multilocularis | microsomal triglyceride transfer protein large | 0.076 | 1 | 1 |
Plasmodium falciparum | topoisomerase I | 0.0581 | 0.7622 | 0.5 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0581 | 0.7622 | 0.7622 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0435 | 0.5677 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.005 | 0.0543 | 0.0543 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0016 | 0.0097 | 0.0097 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0435 | 0.5677 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0 | 0.5 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0581 | 0.7622 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0435 | 0.5677 | 0.5677 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0435 | 0.5677 | 0.5677 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0056 | 0.0624 | 0.0624 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0486 | 0.0486 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.5622 | 0.5622 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.0624 | 0.0624 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0581 | 0.7622 | 0.7622 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.004 | 0.0405 | 0.0405 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0041 | 0.0431 | 0.0431 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0435 | 0.5677 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.005 | 0.0543 | 0.0543 |
Entamoeba histolytica | protein kinase, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | Lipid transport protein N terminal | 0.0431 | 0.5622 | 0.5622 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0016 | 0.0097 | 0.0097 |
Echinococcus multilocularis | Lipid transport protein, N terminal | 0.0431 | 0.5622 | 0.5622 |
Trichomonas vaginalis | AGC family protein kinase | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0056 | 0.0624 | 0.0624 |
Brugia malayi | DNA topoisomerase I | 0.0581 | 0.7622 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0015 | 0.0081 | 0.0081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILS (functional) | = 203 % | Compound was evaluated for antitumor activity against L1210 leukemia in mice and percent increase in life span was determined. | ChEMBL. | 6699882 |
ILS (functional) | = 203 % | Compound was evaluated for antitumor activity against L1210 leukemia in mice and percent increase in life span was determined. | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.0000000012 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.0000000012 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000000011 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000000011 % | Compound was evaluated for 50% inhibition of the enzyme Dihydrofolate reductase (DHFR) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000038 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.000038 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Streptococcus faecium | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.00012 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (binding) | = 0.00012 % | Compound was evaluated for 50% inhibition of the enzyme Thymidylate synthase (TS) from Lactobacillus casei | ChEMBL. | 6699882 |
Inhibition (functional) | = 0.004 % | Compound was evaluated for 50% inhibition of the growth of Lactobacillus casei ATCC7469 strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | = 0.04 % | Compound was evaluated for 50% inhibition of the growth of Streptococcus faecium ATCC8043 strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | = 3 % | Compound was evaluated for 50% inhibition of the growth of Pediococcus cerevisiae at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | = 700 % | Compound was evaluated for 50% inhibition of the growth of Streptococcus faecium MTX resistant strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
Inhibition (functional) | > 2000 % | Compound was evaluated for 50% inhibition of the growth of Lactobacillus casei MTX resistant strain at folate concentration 1 ng/mL | ChEMBL. | 6699882 |
LD10 (ADMET) | = 0.6 mg kg-1 | Compound was evaluated for antitumor activity against L1210 leukemia in mice and LD10 was determined 24 hour after subcutaneous administration of the compound in 10 E 6 cells implanted intraperitoneally. | ChEMBL. | 6699882 |
LD10 (ADMET) | = 0.6 mg kg-1 | Compound was evaluated for antitumor activity against L1210 leukemia in mice and LD10 was determined 24 hour after subcutaneous administration of the compound in 10 E 6 cells implanted intraperitoneally. | ChEMBL. | 6699882 |
MST (functional) | = 21.5 day | Compound was evaluated for antitumor activity against L1210 leukemia in mice and median survival time was determined at ten mice per run. | ChEMBL. | 6699882 |
MST (functional) | = 21.5 day | Compound was evaluated for antitumor activity against L1210 leukemia in mice and median survival time was determined at ten mice per run. | ChEMBL. | 6699882 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.