Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene monooxygenase, putative | 0.1491 | 0.5 | 0.5 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.1491 | 0.5 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.1491 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 201 uM | Concentration required to reduce the viability of mock-infected MT-4 cells | ChEMBL. | 7830280 |
EC50 (functional) | = 14.852 uM | Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-1(IIIB) virus strain in MT-4 cells | ChEMBL. | 7830280 |
EC50 (functional) | = 69.713 uM | Concentration required to protect the virus infected cells against viral cytopathicity was measured on HIV-2(ROD) virus strain in MT-4 cells | ChEMBL. | 7830280 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.