Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 3 | References | |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | References | |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0136 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0079 | 0.2768 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.9857 | 1 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0079 | 0.2768 | 0.2768 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0079 | 0.2768 | 0.2808 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0136 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0079 | 0.2768 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0079 | 0.2768 | 0.2768 |
Schistosoma mansoni | protein kinase | 0.0136 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0136 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0079 | 0.2768 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0079 | 0.2768 | 0.2808 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0135 | 0.9857 | 0.9857 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0136 | 1 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0079 | 0.2768 | 0.2768 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0136 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 92 nM | Inhibition of PAK1/2/3 in human EBC1 cells assessed as MEK1 phosphorylation level at Serine298 residue incubated for 2 hrs by HTRF assay | ChEMBL. | 27346791 |
Ki (binding) | = 25 nM | Inhibition of recombinant human GST-tagged PAK1 kinase domain expressed in baculovirus expression system assessed as suppression of phosphorylation of coumarin/fluorescein-labelled FRET peptide substrate at Ser/Thr19 residues preincubated with substrate for 10 mins followed by enzyme addition measured after 60 mins by Z-Lyte assay | ChEMBL. | 27346791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.