Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 3 | References | |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 1 | References | |
Homo sapiens | p21 protein (Cdc42/Rac)-activated kinase 2 | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0079 | 0.2768 | 0.2808 |
Brugia malayi | p21/Cdc42/Rac1-activated kinase | 0.0079 | 0.2768 | 0.2768 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0079 | 0.2768 | 0.2768 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.9857 | 1 |
Schistosoma mansoni | protein kinase | 0.0136 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKA protein kinase | 0.0079 | 0.2768 | 0.2808 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.0079 | 0.2768 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0136 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0136 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0136 | 1 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0079 | 0.2768 | 0.2768 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.0079 | 0.2768 | 0.5 |
Entamoeba histolytica | p21-activated kinase | 0.0136 | 1 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0136 | 1 | 1 |
Trichomonas vaginalis | mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative | 0.0079 | 0.2768 | 0.2768 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0136 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0135 | 0.9857 | 0.9857 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 250 nM | Inhibition of PAK1/2/3 in human EBC1 cells assessed as MEK1 phosphorylation level at Serine298 residue incubated for 2 hrs by HTRF assay | ChEMBL. | 27346791 |
Ki (binding) | = 68 nM | Inhibition of recombinant human GST-tagged PAK1 kinase domain expressed in baculovirus expression system assessed as suppression of phosphorylation of coumarin/fluorescein-labelled FRET peptide substrate at Ser/Thr19 residues preincubated with substrate for 10 mins followed by enzyme addition measured after 60 mins by Z-Lyte assay | ChEMBL. | 27346791 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.