Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alanyl (membrane) aminopeptidase | References | |
Homo sapiens | endoplasmic reticulum aminopeptidase 2 | References | |
Sus scrofa | Aminopeptidase N | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Brugia malayi | Peptidase family M1 containing protein | endoplasmic reticulum aminopeptidase 2 | 960 aa | 877 aa | 31.0 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0328 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.6484 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0328 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0246 | 0.3516 | 0.5422 |
Echinococcus multilocularis | aminopeptidase N | 0.0328 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.88 uM | Inhibition of pig kidney alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | ChEMBL. | 27100031 |
Ki (binding) | = 10.6 uM | Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | ChEMBL. | 27100031 |
Ki (binding) | = 16.9 uM | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Ki (binding) | = 19 uM | Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis | ChEMBL. | 27100031 |
Ki (binding) | > 250 uM | Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.