Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 1 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activation (functional) | = 70 % | In vitro maximum activation of adenylyl cyclase compared to isoproteronol. | ChEMBL. | 11212115 |
Activation (functional) | = 70 % | In vitro maximum activation of adenylyl cyclase compared to isoproteronol. | ChEMBL. | 11212115 |
EC50 (binding) | = 26 nM | In vitro efficacy at human beta-3 adrenergic receptor. | ChEMBL. | 11212115 |
EC50 (binding) | = 26 nM | In vitro efficacy at human beta-3 adrenergic receptor. | ChEMBL. | 11212115 |
IC50 (binding) | = 40 nM | Binding affinity to the human beta-2 adrenergic receptor assayed using [125I]-iodocyanopindolol as radioligand in CHO cells | ChEMBL. | 11212115 |
IC50 (binding) | = 40 nM | Binding affinity to the human beta-2 adrenergic receptor assayed using [125I]-iodocyanopindolol as radioligand in CHO cells | ChEMBL. | 11212115 |
IC50 (binding) | = 240 nM | Binding affinity for human Beta-1 adrenergic receptor using [125I]-iodocyanopindolol as radioligand in CHO cells | ChEMBL. | 11212115 |
IC50 (binding) | = 240 nM | Binding affinity for human Beta-1 adrenergic receptor using [125I]-iodocyanopindolol as radioligand in CHO cells | ChEMBL. | 11212115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.