Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | CREB binding protein | 0.0122 | 0.2983 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0938 | 0.3332 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0345 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0117 | 0.2816 | 0.2816 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0117 | 0.2816 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0117 | 0.2816 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Plasmodium falciparum | plasmepsin II | 0.0117 | 0.2816 | 1 |
Brugia malayi | TAZ zinc finger family protein | 0.0122 | 0.2983 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0117 | 0.2816 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.2816 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0117 | 0.2816 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0117 | 0.2816 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0117 | 0.2816 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0117 | 0.2816 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0117 | 0.2816 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0117 | 0.2816 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0122 | 0.2983 | 0.2983 |
Loa Loa (eye worm) | CBP-B | 0.0085 | 0.1806 | 0.6413 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0117 | 0.2816 | 0.8864 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0122 | 0.2983 | 0.2983 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0117 | 0.2816 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A level using histone H4 substrate at 400 uM after 15 mins by CPM fluorescence assay | ChEMBL. | 26505788 | |
logIC50 (binding) | > 2.8 | Inhibition of recombinant N-terminal His6-tagged KAT8 (unknown origin) expressed in Escherichia Coli BL21 DE3 cells assessed as reduction of Co A level using histone H4 substrate after 15 mins by CPM fluorescence assay | ChEMBL. | 26505788 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.