Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.002 | 0.0009 | 0.002 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0321 | 0.0712 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0142 | 0.2806 | 0.6096 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0216 | 0.4508 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0053 | 0.0763 | 0.1692 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.002 | 0.0009 | 0.0009 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0216 | 0.4508 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0043 | 0.0523 | 0.116 |
Brugia malayi | hypothetical protein | 0.002 | 0.0009 | 0.002 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0053 | 0.0763 | 0.0763 |
Brugia malayi | jmjC domain containing protein | 0.0054 | 0.0776 | 0.1722 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0009 | 0.002 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0054 | 0.0776 | 0.1722 |
Schistosoma mansoni | N-myristoyltransferase | 0.0216 | 0.4508 | 1 |
Schistosoma mansoni | kinase | 0.0027 | 0.0164 | 0.0364 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0053 | 0.0763 | 0.1676 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0216 | 0.4508 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0189 | 0.042 |
Giardia lamblia | CDC72 | 0.0216 | 0.4508 | 1 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0216 | 0.4508 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0216 | 0.4508 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0216 | 0.4508 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Echinococcus granulosus | jumonji domain containing protein | 0.0023 | 0.0068 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.3442 | 0.7635 |
Leishmania major | N-myristoyl transferase, putative | 0.0216 | 0.4508 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0216 | 0.4508 | 0.4508 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0216 | 0.4508 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.0216 | 0.4508 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0053 | 0.0763 | 0.1692 |
Brugia malayi | N-myristoyltransferase 2 | 0.0216 | 0.4508 | 1 |
Onchocerca volvulus | 0.017 | 0.3442 | 1 | |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0053 | 0.0763 | 0.1692 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.0763 | 0.1692 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0216 | 0.4508 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0023 | 0.0068 | 0.0068 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0054 | 0.0776 | 0.0776 |
Brugia malayi | hypothetical protein | 0.017 | 0.3442 | 0.7635 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0216 | 0.4508 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0053 | 0.0763 | 0.1411 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.002 | 0.0009 | 0.002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 uM | Inhibition of Candida albicans N-myristoyltransferase (NMT) with peptide GNAASARR-NH2 and [3H]-myristoyl-CoA at 1 uM | ChEMBL. | No reference |
IC50 (binding) | = 9 uM | Inhibition of Candida albicans N-myristoyltransferase (NMT) with peptide GNAASARR-NH2 and [3H]-myristoyl-CoA at 1 uM | ChEMBL. | No reference |
IC50 (binding) | >= 200 uM | Tested for Inhibitory concentration against human N-myristoyltransferase (NMT) in radiochemical HPLC end point assay with peptide GNAASARR-NH2 and [3H]-myristoyl-CoA radioligand at 1 uM | ChEMBL. | No reference |
IC50 (binding) | >= 200 uM | Tested for Inhibitory concentration against human N-myristoyltransferase (NMT) in radiochemical HPLC end point assay with peptide GNAASARR-NH2 and [3H]-myristoyl-CoA radioligand at 1 uM | ChEMBL. | No reference |
Ratio (binding) | >= 25 | Selectivity ratio of the IC50 against human NMT to the IC50 against C. albicans NMT was determined | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.