Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | References | |
Homo sapiens | alanyl (membrane) aminopeptidase | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0084 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.5828 | 0.683 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0084 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0084 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0286 | 1 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0084 | 0 | 0.5 |
Onchocerca volvulus | 0.0286 | 1 | 1 | |
Echinococcus granulosus | aminopeptidase N | 0.0286 | 1 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0084 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0084 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0232 | 0.7295 | 0.8549 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0084 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0084 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.341 uM | Inhibition of recombinant human alanyl aminopeptidase M1 using Ala-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis | ChEMBL. | 27100031 |
Ki (binding) | = 2.3 uM | Inhibition of pig kidney alanyl aminopeptidase M1 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis | ChEMBL. | 27100031 |
Ki (binding) | = 106 uM | Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Ki (binding) | > 250 uM | Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method | ChEMBL. | 27390066 |
Ki (binding) | = 350 uM | Inhibition of porcine kidney leucine aminopeptidase M17 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis | ChEMBL. | 27100031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.