Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sirtuin 2 | References | |
Homo sapiens | sirtuin 3 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | transcriptional regulatory protein sir2a | sirtuin 2 | 234 aa | 207 aa | 26.1 % |
Trypanosoma brucei | SIR2-like protein 4, putative | sirtuin 3 | 257 aa | 247 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0269 | 0.5 | 0.5 |
Loa Loa (eye worm) | transcriptional regulator | 0.0269 | 0.5 | 0.5 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.0269 | 0.5 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0269 | 0.5 | 0.5 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.0269 | 0.5 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0269 | 0.5 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0269 | 0.5 | 0.5 |
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.0269 | 0.5 | 0.5 |
Leishmania major | silent information regulator 2, putative | 0.0269 | 0.5 | 0.5 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.0269 | 0.5 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0269 | 0.5 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0269 | 0.5 | 0.5 |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.0269 | 0.5 | 0.5 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.0269 | 0.5 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.0269 | 0.5 | 0.5 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.0269 | 0.5 | 0.5 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.0269 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0234 uM | Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence analysis | ChEMBL. | 26982234 |
IC50 (binding) | = 1.59 uM | Inhibition of human SIRT3 (102 to 399 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence analysis | ChEMBL. | 26982234 |
IC50 (binding) | = 52.1 uM | Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence analysis | ChEMBL. | 26982234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.