Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | perforin-like protein 1 | 0.0009 | 0.5 | 0.5 |
Plasmodium vivax | perforin-like protein 5 | 0.0009 | 0.5 | 0.5 |
Plasmodium vivax | perforin-like protein 4 | 0.0009 | 0.5 | 0.5 |
Echinococcus granulosus | macrophage expressed protein | 0.0009 | 0.5 | 0.5 |
Plasmodium vivax | perforin-like protein 2 | 0.0009 | 0.5 | 0.5 |
Plasmodium vivax | perforin-like protein 3 | 0.0009 | 0.5 | 0.5 |
Plasmodium falciparum | perforin-like protein 5 | 0.0009 | 0.5 | 0.5 |
Plasmodium falciparum | perforin-like protein 2 | 0.0009 | 0.5 | 0.5 |
Toxoplasma gondii | perforin-like protein PLP1 | 0.0009 | 0.5 | 0.5 |
Plasmodium falciparum | perforin-like protein 3 | 0.0009 | 0.5 | 0.5 |
Plasmodium falciparum | perforin-like protein 4 | 0.0009 | 0.5 | 0.5 |
Echinococcus multilocularis | macrophage expressed protein | 0.0009 | 0.5 | 0.5 |
Plasmodium falciparum | perforin-like protein 1 | 0.0009 | 0.5 | 0.5 |
Toxoplasma gondii | MAC/Perforin domain-containing protein | 0.0009 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibition of recombinant perforin (unknown origin) mediated lysis of human Jurkat cells pre-incubated for 30 mins with perforin followed by incubation with Jurkat cells at 37 degC for 4 hrs assessed as 51Cr release by gamma counting analysis | ChEMBL. | 26711151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.