Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphoglycerate kinase 1 | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | phosphoglycerate kinase | phosphoglycerate kinase 1 | 417 aa | 373 aa | 41.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Treponema pallidum | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0103 | 0.5 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0103 | 0.5 | 0.5 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0103 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0103 | 0.5 | 0.5 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0103 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.5 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0103 | 0.5 | 0.5 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0103 | 0.5 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0103 | 0.5 | 0.5 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0103 | 0.5 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0103 | 0.5 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0103 | 0.5 | 0.5 |
Giardia lamblia | Phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0103 | 0.5 | 0.5 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0103 | 0.5 | 0.5 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0103 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | Inhibition of PGK1 (unknown origin) pre-incubated with enzyme before 3-phosphoglycerate substrate addition and incubated for 30 mins in presence of NADH and ATP by glyceraldehyde P-dehydrogenase coupling based NADH fluorescence assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.