Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0158 | 0.3647 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0193 | 0.4541 | 1 |
Onchocerca volvulus | 0.0158 | 0.3647 | 1 | |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0193 | 0.4541 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0193 | 0.4541 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0193 | 0.4541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0193 | 0.4541 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1141 | 0.2513 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0091 | 0.1933 | 0.4256 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0193 | 0.4541 | 0.3233 |
Echinococcus granulosus | carbonic anhydrase II | 0.0193 | 0.4541 | 0.3233 |
Plasmodium falciparum | carbonic anhydrase | 0.0091 | 0.1933 | 0.5 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Schistosoma mansoni | carbonic anhydrase | 0.0091 | 0.1933 | 0.2328 |
Leishmania major | carbonic anhydrase-like protein | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.1933 | 0.2328 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0091 | 0.1933 | 0.4256 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0193 | 0.4541 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0091 | 0.1933 | 0.4256 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Brugia malayi | hypothetical protein | 0.0158 | 0.3647 | 0.8032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 nM | Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.