Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.0742 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0677 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0668 | 0.984 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0453 | 0.6107 | 0.4101 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0742 | 1 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0668 | 0.984 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0668 | 0.984 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0677 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.0742 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 nM | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | ChEMBL. | 8254620 |
IC50 (binding) | = 2.4 nM | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | ChEMBL. | 8254620 |
IC50 (binding) | = 24 uM | Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined | ChEMBL. | 8254620 |
Inhibition (functional) | = -18 % | Inhibition of arachidonic acid induced mouse ear edema at 30 microg/ear | ChEMBL. | 8254620 |
Inhibition (functional) | = -18 % | Inhibition of arachidonic acid induced mouse ear edema at 30 microg/ear | ChEMBL. | 8254620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.