Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0129 | 0.1764 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0667 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0658 | 0.986 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0076 | 0.0959 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0658 | 0.986 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0446 | 0.661 | 0.6348 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0298 | 0.4349 | 0.3809 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1764 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.007 | 0.0858 | 0.4866 |
Echinococcus multilocularis | serotonin receptor | 0.0129 | 0.1764 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0298 | 0.4349 | 0.375 |
Schistosoma mansoni | amine GPCR | 0.0328 | 0.4804 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1764 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.007 | 0.0858 | 0.4866 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0129 | 0.1764 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0446 | 0.661 | 0.6348 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0667 | 1 | 0.5 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0658 | 0.986 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0446 | 0.661 | 0.6348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 2 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 10 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Activity rating (functional) | = 0 | Effect on heart rate of spontaneously hypertensive rats, 24 hr after peroral administration at 50 mg/kg | ChEMBL. | 7265125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.