TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 502.726 | Formula: C31H50O5
H donors: 3 H acceptors: 4 LogP: 6.03 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@]12CC[C@H]([C@@H](C2C2=CCC3[C@@]([C@@]2(CC1)C)(C)CCC1[C@]3(C)C[C@H]([C@@H]([C@@]1(C)CO)O)O)C)C
InChi: 1S/C31H50O5/c1-18-10-13-31(26(35)36-7)15-14-29(5)20(24(31)19(18)2)8-9-23-27(3)16-21(33)25(34)28(4,17-32)22(27)11-12-30(23,29)6/h8,18-19,21-25,32-34H,9-17H2,1-7H3/t18-,19+,21-,22?,23?,24?,25+,27+,28+,29-,30-,31+/m1/s1
InChiKey: PTVQHIGQUFDPIQ-OJFQKVMMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0367	0.0352
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0137	0.2737	0.3604
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0367	0.1175
Leishmania major	pyruvate kinase	0.0034	0.0367	0.0787
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0347	0.0301
Trichomonas vaginalis	CMGC family protein kinase	0.0047	0.0669	0.2263
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0034	0.0367	0.0324
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.032	0.1015
Plasmodium falciparum	DNA topoisomerase 2	0.0137	0.2737	0.2703
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.032	0.0366
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0132	0.0085
Plasmodium vivax	protein kinase Crk2	0.0047	0.0669	0.0625
Echinococcus multilocularis	cyclin dependent kinase	0.0047	0.0669	0.0834
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0347	0.0336
Leishmania major	glucose transporter, lmgt3	0.0033	0.0345	0.0712
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0132	0.0252
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0047	0.0669	0.1797
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0345	0.0712
Plasmodium falciparum	pyruvate kinase	0.0034	0.0367	0.0322
Giardia lamblia	Kinase, CMGC CDK	0.0047	0.0669	0.2202
Trichomonas vaginalis	CMGC family protein kinase	0.0047	0.0669	0.2263
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0047	0.0669	0.1797
Echinococcus multilocularis	cyclin dependent kinase 5	0.0047	0.0669	0.0834
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0347	0.0301
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.032	0.0957
Echinococcus granulosus	cyclin dependent kinase 5	0.0047	0.0669	0.0834
Trypanosoma cruzi	cdc2-related kinase 3	0.0047	0.0669	0.2143
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Trypanosoma cruzi	cdc2-related kinase 1	0.0047	0.0669	0.2143
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0347	0.0301
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.032	0.0276
Schistosoma mansoni	protein kinase	0.0033	0.0346	0.1112
Plasmodium vivax	pyruvate kinase, putative	0.0034	0.0367	0.0322
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.032	0.0276
Chlamydia trachomatis	DNA gyrase subunit B	0.0063	0.1037	0.7011
Echinococcus granulosus	pyruvate kinase	0.0034	0.0367	0.0429
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0367	0.1133
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0346	0.0303
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0047	0.0669	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0611	0.0598
Echinococcus multilocularis	cyclin dependent kinase 1	0.0047	0.0669	0.0834
Loa Loa (eye worm)	TOPoisomerase family member	0.0137	0.2737	0.2742
Entamoeba histolytica	cell division protein kinase 2, putative	0.0047	0.0669	0.2067
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0346	0.0331
Plasmodium vivax	DNA gyrase subunit A, putative	0.003	0.0262	0.0217
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0367	0.0429
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.008	0.1423	1
Schistosoma mansoni	pyruvate kinase	0.0034	0.0367	0.119
Chlamydia trachomatis	DNA gyrase subunit A	0.003	0.0262	0.1013
Schistosoma mansoni	protein kinase	0.0033	0.0346	0.1112
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0345	0.0712
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0442	0.1037
Schistosoma mansoni	glucose transport protein	0.0107	0.2036	0.7394
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0047	0.003
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0347	0.0301
Schistosoma mansoni	protein kinase	0.0033	0.0346	0.1112
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0367	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0032	0.032	0.0305
Echinococcus granulosus	General substrate transporter	0.0092	0.1691	0.2203
Plasmodium falciparum	hexose transporter	0.0107	0.2036	0.1998
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0669	0.0629
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Schistosoma mansoni	glucose transport protein	0.0107	0.2036	0.7394
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0367	0.1175
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0367	0.0352
Trypanosoma brucei	cdc2-related kinase 3	0.0047	0.0669	0.1797
Giardia lamblia	Pyruvate kinase	0.0034	0.0367	0.0964
Entamoeba histolytica	protein kinase, putative	0.0033	0.0346	0.0829
Entamoeba histolytica	hypothetical protein	0.0024	0.0132	0.0006
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0132	0.0113
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0173	0.3557	0.3526
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.2036	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0032	0.032	0.0305
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0137	0.2737	0.2721
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1718	0.1714
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0345	0.0712
Brugia malayi	Cam kinase protein 1	0.0033	0.0346	0.0303
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0442	0.1415
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0132	0.2327
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0132	0.0085
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0442	0.0397
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0454	1	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0346	0.0717
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.032	0.0366
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0346	0.1055
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.013	0.2567	0.8141
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0347	0.0301
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0173	0.3557	0.536
Loa Loa (eye worm)	pyruvate kinase-PB	0.0024	0.013	0.0113
Loa Loa (eye worm)	runx1	0.0057	0.0883	0.0872
Mycobacterium ulcerans	DNA gyrase subunit A	0.003	0.0262	0.1013
Plasmodium vivax	DNA gyrase subunit B, putative	0.008	0.1423	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0166
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0345	0.105
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0289	0.0324
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0669	0.2313
Leishmania major	mitochondrial DNA topoisomerase II	0.0154	0.3123	1
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0367	0.0352
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0367	0.0324
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0346	0.1112
Leishmania major	protein kinase, putative	0.0033	0.0346	0.0717
Leishmania major	glucose transporter, lmgt2	0.0033	0.0345	0.0712
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0132	0.0113
Echinococcus multilocularis	General substrate transporter	0.0092	0.1691	0.2203
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0137	0.2737	0.2721
Schistosoma mansoni	serine/threonine protein kinase	0.0047	0.0669	0.2313
Trichomonas vaginalis	CMGC family protein kinase	0.0047	0.0669	0.2263
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Onchocerca volvulus		0.0051	0.0745	0.0706
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0093	0.1715	0.1687
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0442	0.0485
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0345	0.0712
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0034	0.0367	0.2314
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0346	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1718	0.1714
Plasmodium falciparum	DNA gyrase subunit A	0.003	0.0262	0.0217
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.032	0.0728
Echinococcus granulosus	tumor protein p63	0.0345	0.751	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0345	0.0712
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0345	0.1104
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0345	0.1104
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0345	0.105
Trypanosoma brucei	pyruvate kinase 1, putative	0.0034	0.0367	0.0787
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0132	0.0315
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.032	0.0771
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.003	0.0262	0.1553
Loa Loa (eye worm)	hypothetical protein	0.002	0.0047	0.003
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0093	0.1715	0.1687
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0132	0.0086
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0745	0.2593
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.032	0.1015
Trypanosoma cruzi	cdc2-related kinase 3	0.0047	0.0669	0.2143
Schistosoma mansoni	glucose transport protein	0.0107	0.2036	0.7394
Plasmodium vivax	DNA topoisomerase II, putative	0.0137	0.2737	0.2703
Echinococcus multilocularis	tumor protein p63	0.0345	0.751	1
Toxoplasma gondii	pyruvate kinase PyK1	0.0034	0.0367	0.0368
Brugia malayi	Probable DNA topoisomerase II	0.0137	0.2737	0.2721
Loa Loa (eye worm)	hypothetical protein	0.0451	0.9934	1
Schistosoma mansoni	DNA topoisomerase II	0.0137	0.2737	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0442	0.1037
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0346	0.0331
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0345	0.105
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0047	0.0669	0.0657
Loa Loa (eye worm)	sugar transporter	0.0107	0.2036	0.2035
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0036	0.0404	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0367	0.0352
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0047	0.0669	0.0841
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0132	0.0315
Leishmania major	glucose transporter, lmgt1	0.0033	0.0345	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0867	0.0856
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.013	0.2567	0.8141
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0345	0.105
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0047	0.0669	0.0834
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0347	0.0336
Echinococcus multilocularis	pyruvate kinase	0.0027	0.0202	0.0208
Leishmania major	DNA topoisomerase ii	0.013	0.2567	0.8141
Trypanosoma brucei	pyruvate kinase 1	0.0034	0.0367	0.0787
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0137	0.2737	1
Echinococcus multilocularis	Protein lozenge	0.0057	0.0883	0.112
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0345	0.105
Entamoeba histolytica	cell division protein kinase 2, putative	0.0047	0.0669	0.2067
Trypanosoma cruzi	hexose transporter	0.0033	0.0345	0.1104
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0047	0.0669	0.0657
Echinococcus granulosus	cyclin dependent kinase	0.0047	0.0669	0.0834
Plasmodium falciparum	DNA gyrase subunit B	0.008	0.1423	0.1382
Trypanosoma brucei	cdc2-related kinase 1	0.0047	0.0669	0.1797
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.2036	0.298
Brugia malayi	Sugar transporter family protein	0.0107	0.2036	0.2012
Chlamydia trachomatis	pyruvate kinase	0.0034	0.0367	0.1823
Giardia lamblia	Kinase, CMGC CDK	0.0047	0.0669	0.2202
Trypanosoma cruzi	DNA topoisomerase II, putative	0.013	0.2567	0.822
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0442	0.1415
Mycobacterium ulcerans	pyruvate kinase	0.0034	0.0367	0.1823
Mycobacterium ulcerans	DNA gyrase subunit B	0.008	0.1423	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0047	0.0669	0.2143
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0745	0.0733
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0442	0.1037
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0137	0.2737	0.3604
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0346	0.0401
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.2036	0.7377
Plasmodium falciparum	protein kinase 7	0.0302	0.6522	0.6505
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0137	0.2737	0.4077
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.008	0.1423	0.202
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0173	0.3557	0.3526
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0345	0.0712
Entamoeba histolytica	protein kinase, putative	0.0033	0.0346	0.0829
Echinococcus multilocularis	cyclin dependent kinase 1	0.0047	0.0669	0.0834
Loa Loa (eye worm)	hypothetical protein	0.0451	0.9934	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.013	0.2567	0.822
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0867	0.0856
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Plasmodium vivax	hexose transporter	0.0107	0.2036	0.1998
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0346	0.0401
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0093	0.1715	0.1687
Schistosoma mansoni	hypothetical protein	0.0107	0.2036	0.7394
Brugia malayi	hypothetical protein	0.0451	0.9934	1
Toxoplasma gondii	protein kinase, putative	0.0302	0.6522	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0347	0.0301
Entamoeba histolytica	DNA topoisomerase II, putative	0.0137	0.2737	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0115
Schistosoma mansoni	pyruvate kinase	0.0034	0.0367	0.119
Trypanosoma brucei	DNA topoisomerase ii	0.0154	0.3123	1
Brugia malayi	cell division control protein 2 homolog	0.0047	0.0669	0.0629
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.032	0.7639
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.008	0.1423	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0347	0.0336
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0347	0.0301
Leishmania major	pyruvate kinase	0.0034	0.0367	0.0787
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0289	0.0324
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0034	0.0367	0.0324
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0345	0.105
Giardia lamblia	DNA topoisomerase II	0.013	0.2573	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0367	0.0324
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0034	0.0367	0.8966
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0345	0.1104
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0154	0.3123	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Schistosoma mansoni	lozenge	0.0057	0.0883	0.3107
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.003	0.0262	0.0205
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0367	0.1133
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0879	0.1115
Echinococcus granulosus	cyclin dependent kinase 1	0.0047	0.0669	0.0834
Chlamydia trachomatis	DNA gyrase subunit B	0.008	0.1423	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0347	0.0301
Loa Loa (eye worm)	hypothetical protein	0.002	0.0047	0.003
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0154	0.3123	1
Plasmodium falciparum	protein kinase 5	0.0047	0.0669	0.0625
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0879	0.1115
Onchocerca volvulus		0.0451	0.9934	1
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.008	0.1423	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2036	0.2665
Echinococcus granulosus	pyruvate kinase	0.0034	0.0367	0.0429
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0345	0.105
Schistosoma mansoni	lipoxygenase	0.0056	0.0879	0.3095
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0442	0.0397
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0345	0.0712
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0367	0.0324
Chlamydia trachomatis	DNA gyrase subunit A	0.003	0.0262	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0024	0.013	0.0113
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0132	0.0421
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0347	0.0301

Activities

Activity type	Activity value	Assay description	Source	Reference
Protection (functional)	= 58 %	Compound was evaluated in vitro for percent protective effect against Amyloid Beta(A beta)-induced neurotoxicity in B103 cells	ChEMBL.	10673093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 22182