Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0063 | 1 | 0.5 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0063 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0063 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (ADMET) | = 33 mg kg-1 | Dose required for 100%, 31 day survival of Plasmodium berghai inoculated mice. | ChEMBL. | 11689078 |
Dose (ADMET) | = 33 mg kg-1 | Dose required for 100%, 31 day survival of Plasmodium berghai inoculated mice. | ChEMBL. | 11689078 |
ED (ADMET) | = 16 mg kg-1 | Dose needed to increase the 100% survival of treated animals (mouse), to twice the number of days | ChEMBL. | 11689078 |
ED (ADMET) | = 16 mg kg-1 | Dose needed to increase the 100% survival of treated animals (mouse), to twice the number of days | ChEMBL. | 11689078 |
ED90 (functional) | < 16 mg kg-1 | In vivo antimalarial activity against P. berghei in mouse after 6 days of administration | ChEMBL. | 11689078 |
IC50 (functional) | = 845 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6) | ChEMBL. | 15828818 |
IC50 (functional) | = 845 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6) | ChEMBL. | 15828818 |
IC50 (functional) | = 2551 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2) | ChEMBL. | 15828818 |
IC50 (functional) | = 2551 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2) | ChEMBL. | 15828818 |
Km (ADMET) | = 176 uM | Michaelis menton constant value of the compound against human liver microsomes; (n=6) | ChEMBL. | 15828818 |
Km (ADMET) | = 176 uM | Michaelis menton constant value of the compound against human liver microsomes; (n=6) | ChEMBL. | 15828818 |
Vmax (ADMET) | = 27.7 nmol/min/mg | Maximum velocity of the compound against human liver microsomes; (n=6) | ChEMBL. | 15828818 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15828818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.