Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.101 | 0.1043 | 0.085 |
Loa Loa (eye worm) | calcium channel | 0.101 | 0.1043 | 0.1043 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.101 | 0.1043 | 0.0986 |
Onchocerca volvulus | 0.8819 | 1 | 0.5 | |
Echinococcus multilocularis | voltage dependent calcium channel | 0.101 | 0.1043 | 0.085 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.101 | 0.1043 | 0.0986 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.101 | 0.1043 | 0.085 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0185 | 0.0096 | 0.0079 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0285 | 0.0211 | 0.0149 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.101 | 0.1043 | 0.0941 |
Echinococcus granulosus | voltage dependent calcium channel | 0.101 | 0.1043 | 0.0986 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.8819 | 1 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0185 | 0.0096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.8819 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0132 | 0.0036 | 0.0019 |
Brugia malayi | hypothetical protein | 0.3561 | 0.3968 | 0.3266 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0156 | 0.0063 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.101 | 0.1043 | 0.0941 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.101 | 0.1043 | 0.085 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.101 | 0.1043 | 0.085 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0391 | 0.0333 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0063 | 0.0063 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0391 | 0.0333 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0132 | 0.0036 | 0.0019 |
Echinococcus multilocularis | translocator protein | 0.8819 | 1 | 1 |
Onchocerca volvulus | 0.8819 | 1 | 0.5 | |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0391 | 0.0333 | 0.5 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0259 | 0.0181 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.1043 | 0.1043 |
Schistosoma mansoni | lipoxygenase | 0.0285 | 0.0211 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.8819 | 1 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.101 | 0.1043 | 0.0941 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.101 | 0.1043 | 0.0986 |
Onchocerca volvulus | 0.8819 | 1 | 0.5 | |
Toxoplasma gondii | transporter, cation channel family protein | 0.0156 | 0.0063 | 1 |
Echinococcus granulosus | translocator protein | 0.8819 | 1 | 1 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0156 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.8819 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.101 | 0.1043 | 0.085 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0156 | 0.0063 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0185 | 0.0096 | 0.0079 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.8819 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.8819 | 1 | 1 |
Onchocerca volvulus | 0.8819 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cmax (ADMET) | = 101 uM | Plasma Cmax in rat (PO dose) | ChEMBL. | 8831760 |
IC50 (functional) | = 3.5 uM | In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes. | ChEMBL. | 8831760 |
IC50 (functional) | = 3.5 uM | In vitro 5-lipoxygenase inhibitory activity against calcium ionophore (A23187) induced LTB4 formation in human polymorphonuclear leukocytes. | ChEMBL. | 8831760 |
IC50 (binding) | = 9.5 uM | Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation | ChEMBL. | 8831760 |
IC50 (binding) | = 9.5 uM | Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation | ChEMBL. | 8831760 |
Inhibition (functional) | = 26 % | In vivo inhibition of rat anaphylaxis LTE4 leukotriene formation from peritoneal fluids, 1 h after an oral dose of 200 microM/kg | ChEMBL. | 8831760 |
T max (ADMET) | = 1 hr | Plasma Tmax in rat (PO dose) | ChEMBL. | 8831760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.