Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | probable zinc metalloprotease | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5172 | 0.5172 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0721 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.4828 | 0.4828 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0533 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0721 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.4828 | 0.4828 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0533 | 0.4828 | 0.4828 |
Toxoplasma gondii | peptidase family M13 protein | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0721 | 1 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5172 | 0.5172 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5172 | 0.5172 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0721 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.4828 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0721 | 1 | 1 |
Onchocerca volvulus | 0.0357 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.5172 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0533 | 0.4828 | 0.4828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.36 uM | Inhibition of ADP-induced platelet aggregation in canine platelet-rich plasma | ChEMBL. | 1433204 |
Ki (binding) | = 0.175 uM | Inhibition of [3H]-107260 binding to purified GPIIb/IIIa of human platelets | ChEMBL. | 1433204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.