Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Loa Loa (eye worm) | ctsf protein | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.052 | 0.052 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0164 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.052 | 0.052 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0164 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | Cathepsin F homolog | 0.0023 | 0.052 | 0.052 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0164 | 1 | 1 |
Plasmodium vivax | RNA helicase-1, putative | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.052 | 0.052 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0023 | 0.052 | 0.052 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0164 | 1 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0023 | 0.052 | 0.052 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0164 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.052 | 0.052 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Echinococcus granulosus | cathepsin l1 | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0164 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0164 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0164 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.052 | 0.052 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0164 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.052 | 0.052 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0023 | 0.052 | 0.052 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0164 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0164 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.052 | 0.052 |
Loa Loa (eye worm) | fibroinase | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0164 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Onchocerca volvulus | 0.0023 | 0.052 | 0.052 | |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.052 | 0.052 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0023 | 0.052 | 0.052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.12 mg kg-1 | Tested for potentiation of gamma-butyrolactone induced sleep (gamma-B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.12 mg kg-1 | Tested for potentiation of gamma-butyrolactone induced sleep (gamma-B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.3 mg kg-1 | Tested for antagonism of nicotine-induced tonic extensor convulsions (TE) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.3 mg kg-1 | Tested for antagonism of nicotine-induced tonic extensor convulsions (TE) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.35 mg kg-1 | Tested for antagonism of nicotine-induced death (D) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.35 mg kg-1 | Tested for antagonism of nicotine-induced death (D) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.6 mg kg-1 | Tested for antagonism of bicuculline-induced tonic-extensor convulsions (B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.6 mg kg-1 | Tested for antagonism of pentylenetetrazole-induced clonic convulsions (P) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.6 mg kg-1 | Tested for antagonism of bicuculline-induced tonic-extensor convulsions (B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.6 mg kg-1 | Tested for antagonism of pentylenetetrazole-induced clonic convulsions (P) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 3 mg kg-1 | Prolongation of hypoxic survival time (HS) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 3 mg kg-1 | Prolongation of hypoxic survival time (HS) in mice | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for stereotyped gnawing and licking behavior of mice pretreated with apomorphine (AG) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for antagonism of oxotremorine hypothermia (OX) in mice | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for potentiation of yohimbine toxicity in aggregated mice(Y) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for stereotyped gnawing and licking behavior of mice pretreated with apomorphine (AG) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for antagonism of oxotremorine hypothermia (OX) in mice | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for potentiation of yohimbine toxicity in aggregated mice(Y) | ChEMBL. | 6103958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.