Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Polypeptide deformylase 1 | 0.062 | 0.3707 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0107 | 0.0495 | 0.041 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0107 | 0.0495 | 0.007 |
Plasmodium vivax | peptide deformylase, putative | 0.1626 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0096 | 0.0428 | 0.0342 |
Echinococcus granulosus | geminin | 0.0189 | 0.101 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.0088 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.062 | 0.3707 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.0088 | 0.0088 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0096 | 0.0428 | 0.0342 |
Brugia malayi | glutathione reductase | 0.0042 | 0.0088 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0715 | 0.4766 |
Echinococcus multilocularis | geminin | 0.0189 | 0.101 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0096 | 0.0428 | 0.0342 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.062 | 0.3707 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.0088 | 0.0238 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.0088 | 0.0088 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.101 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0107 | 0.0495 | 0.041 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.062 | 0.3707 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1626 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.0088 | 0.0088 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.0715 | 0.679 |
Leishmania major | trypanothione reductase | 0.0042 | 0.0088 | 0.0238 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.0088 | 0.0088 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.0715 | 0.679 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0096 | 0.0428 | 0.0342 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1626 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.0088 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0107 | 0.0495 | 0.041 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.0088 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0096 | 0.0428 | 0.0342 |
Treponema pallidum | polypeptide deformylase (def) | 0.1626 | 1 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.0088 | 0.0088 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1626 | 1 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.1626 | 1 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.1626 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1626 | 1 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.0088 | 0.0238 |
Mycobacterium tuberculosis | Probable reductase | 0.0096 | 0.0428 | 0.0342 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.101 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.062 | 0.3707 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.062 | 0.3707 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.062 | 0.3707 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cmax (ADMET) | = 20 uM | Plasma Cmax in rat (PO dose) | ChEMBL. | 8831760 |
IC50 (binding) | = 12 uM | Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation | ChEMBL. | 8831760 |
IC50 (binding) | = 12 uM | Inhibition of 5-lipoxygenase catalysis in rat basophilic leukemia (RBL) cells by measuring 5-HETE product formation | ChEMBL. | 8831760 |
Inhibition (functional) | = 46 % | In vivo inhibition of rat anaphylaxis LTE4 leukotriene formation from peritoneal fluids, 1 h after an oral dose of 200 microM/kg | ChEMBL. | 8831760 |
T max (ADMET) | = 4 hr | Plasma Tmax in rat (PO dose) | ChEMBL. | 8831760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.