Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0524 | 1 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.02 | 0.3734 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0013 | 0.0115 | 0.4393 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0179 | 0.0381 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0065 | 0.5013 |
Plasmodium falciparum | peptide deformylase | 0.0524 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0524 | 1 | 0.5 |
Schistosoma mansoni | nephrin | 0.0013 | 0.0115 | 0.892 |
Echinococcus granulosus | twitchin | 0.0013 | 0.0115 | 0.4393 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0179 | 0.0381 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0179 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0524 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0524 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0524 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0524 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.02 | 0.3734 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.02 | 0.3734 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.02 | 0.3734 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0165 | 0.3067 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0013 | 0.0129 | 0.5607 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0065 | 0.5013 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0165 | 0.3067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0129 | 0.0214 |
Treponema pallidum | polypeptide deformylase (def) | 0.0524 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.02 | 0.3734 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0013 | 0.0129 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.02 | 0.3734 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0179 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0065 | 0.5013 |
Trypanosoma brucei | Peptide deformylase 2 | 0.02 | 0.3734 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0013 | 0.0115 | 0.4393 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0154 | 0.2856 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.1 mg kg-1 | Tested for potentiation of gamma-butyrolactone induced sleep (gamma-B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.1 mg kg-1 | Tested for potentiation of gamma-butyrolactone induced sleep (gamma-B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.16 mg kg-1 | Tested for antagonism of nicotine-induced tonic extensor convulsions (TE) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.16 mg kg-1 | Tested for antagonism of nicotine-induced tonic extensor convulsions (TE) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.18 mg kg-1 | Tested for antagonism of nicotine-induced death (D) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.18 mg kg-1 | Tested for antagonism of nicotine-induced death (D) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.4 mg kg-1 | Tested for antagonism of pentylenetetrazole-induced clonic convulsions (P) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.4 mg kg-1 | Tested for antagonism of pentylenetetrazole-induced clonic convulsions (P) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.5 mg kg-1 | Tested for antagonism of bicuculline-induced tonic-extensor convulsions (B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 0.5 mg kg-1 | Tested for antagonism of bicuculline-induced tonic-extensor convulsions (B) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 3.7 mg kg-1 | Tested for antagonism of oxotremorine hypothermia (OX) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 3.7 mg kg-1 | Tested for antagonism of oxotremorine hypothermia (OX) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 12.5 mg kg-1 | Tested for stereotyped gnawing and licking behavior of mice pretreated with apomorphine (AG) | ChEMBL. | 6103958 |
ED50 (functional) | = 12.5 mg kg-1 | Tested for stereotyped gnawing and licking behavior of mice pretreated with apomorphine (AG) | ChEMBL. | 6103958 |
ED50 (functional) | = 40 mg kg-1 | Prolongation of hypoxic survival time (HS) in mice | ChEMBL. | 6103958 |
ED50 (functional) | = 40 mg kg-1 | Prolongation of hypoxic survival time (HS) in mice | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for potentiation of yohimbine toxicity in aggregated mice(Y) | ChEMBL. | 6103958 |
ED50 (functional) | > 50 mg kg-1 | Tested for potentiation of yohimbine toxicity in aggregated mice(Y) | ChEMBL. | 6103958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.