Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | References | |
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0529 | 1 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0202 | 0.2341 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0529 | 1 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0529 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0529 | 1 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.6468 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.4174 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0202 | 0.2341 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.6468 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0202 | 0.2341 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0202 | 0.2341 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0202 | 0.2341 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0529 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0529 | 1 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.2828 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.4278 | 0.6614 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.1009 | 0.156 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0202 | 0.2341 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.4174 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0529 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0529 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0885 | 0.1368 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0202 | 0.2341 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.1938 | 0.1886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | nM | In vitro inhibition of human Platelet-rich plasma (PRP) aggregation induced by 5 uM ADP;nt= Not tested | ChEMBL. | 9767641 |
IC50 (functional) | 0 nM | In vitro inhibition of human Platelet-rich plasma (PRP) aggregation induced by 5 uM ADP;nt= Not tested | ChEMBL. | 9767641 |
IC50 (binding) | = 0.2 nM | Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | ChEMBL. | 9767641 |
IC50 (binding) | = 0.2 nM | Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor. | ChEMBL. | 9767641 |
IC50 (functional) | = 620 nM | In vitro inhibition of guinea pig Platelet-rich plasma (PRP) aggregation induced by 5 uM ADP | ChEMBL. | 9767641 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.