Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1198 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0565 | 0.4637 | 0.4637 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | thyroid hormone receptor | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1198 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0633 | 0.5211 | 0.5211 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1198 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1198 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1198 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1198 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1198 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1198 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1198 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1198 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1198 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1198 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | nuclear hormone receptor | 0.1198 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1198 | 1 | 1 |
Onchocerca volvulus | 0.0565 | 0.4637 | 0.4637 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1198 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0633 | 0.5211 | 0.5211 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1198 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1198 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1198 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | nuclear receptor RXR | 0.0633 | 0.5211 | 0.5211 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0633 | 0.5211 | 0.5211 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0633 | 0.5211 | 0.5211 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1198 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1198 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1198 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1198 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | nuclear hormone receptor | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1198 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | nuclear receptor | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | nuclear hormone receptor | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | tailless protein | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1198 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | nuclear receptor RXR | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1198 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.3306 | 0.3306 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1198 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0633 | 0.5211 | 0.5211 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1198 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1198 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0354 | 0.0354 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1198 | 1 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.3306 | 0.3306 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | nuclear receptor NHR-88 | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1198 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0633 | 0.5211 | 0.5211 |
Brugia malayi | nuclear receptor NHR-67 | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1198 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0565 | 0.4637 | 0.4637 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | nuclear hormone receptor | 0.1198 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.1198 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0633 | 0.5211 | 0.5211 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0633 | 0.5211 | 0.5211 |
Schistosoma mansoni | nuclear hormone receptor | 0.0565 | 0.4637 | 0.4637 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1198 | 1 | 1 |
Onchocerca volvulus | 0.0565 | 0.4637 | 0.4637 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1198 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.1198 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0565 | 0.4637 | 0.4637 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1198 | 1 | 1 |
Onchocerca volvulus | 0.1198 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 0.4637 | 0.4637 |
Schistosoma mansoni | coup transcription factor | 0.1198 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0565 | 0.4637 | 0.4637 |
Onchocerca volvulus | 0.006 | 0.0354 | 0.0354 | |
Loa Loa (eye worm) | hypothetical protein | 0.1198 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.3 nM | Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.