Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Leishmania major | carbonic anhydrase-like protein | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0091 | 0.1933 | 0.2328 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.1933 | 0.2328 |
Leishmania major | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0091 | 0.1933 | 0.4256 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0193 | 0.4541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.3647 | 0.8032 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Brugia malayi | hypothetical protein | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0193 | 0.4541 | 1 |
Toxoplasma gondii | prostaglandin-E synthase | 0.0158 | 0.3647 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0193 | 0.4541 | 1 |
Onchocerca volvulus | 0.0158 | 0.3647 | 1 | |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0193 | 0.4541 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0193 | 0.4541 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0193 | 0.4541 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0193 | 0.4541 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0091 | 0.1933 | 0.2328 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Trypanosoma brucei | Prostaglandin E synthase | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.1933 | 0.4256 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0091 | 0.1933 | 0.4256 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0091 | 0.1933 | 0.4256 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0193 | 0.4541 | 0.3233 |
Trypanosoma cruzi | glutathione-S-transferase/glutaredoxin, putative | 0.0158 | 0.3647 | 0.8032 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1141 | 0.2513 |
Plasmodium falciparum | carbonic anhydrase | 0.0091 | 0.1933 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0193 | 0.4541 | 0.3233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 nM | Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay) | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.