Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gonadotropin-releasing hormone receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | GnHR receptor homolog | Get druggable targets OG5_131719 | All targets in OG5_131719 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0898 | 0.2791 | 0.2791 |
Plasmodium vivax | hypothetical protein, conserved | 0.0212 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0563 | 0.1428 | 0.1428 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0212 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0212 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0898 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0212 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0212 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0898 | 0.2791 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0212 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0686 | 0.193 | 0.193 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0212 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0212 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0898 | 0.2791 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0898 | 0.2791 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0898 | 0.2791 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0898 | 0.2791 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0212 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0686 | 0.193 | 0.193 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2672 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0898 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2672 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0898 | 0.2791 | 0.2791 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2672 | 1 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0212 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0212 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0212 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0212 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0212 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0212 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2672 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2672 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0212 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0898 | 0.2791 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0212 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.4 uM | Binding affinity against human GnRH receptor expressed in HEK293 cells using des-Gly10[125I]Tyr5, D-Leu, NMeLeu, Pro-NEt GnRH as radioligand. | ChEMBL. | 11814806 |
Ki (binding) | = 0.4 uM | Binding affinity against human GnRH receptor expressed in HEK293 cells using des-Gly10[125I]Tyr5, D-Leu, NMeLeu, Pro-NEt GnRH as radioligand. | ChEMBL. | 11814806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.