Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1038 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1038 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1038 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1038 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0367 | 0.2597 | 0.234 |
Echinococcus granulosus | cathepsin b | 0.1038 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0322 | 0.2106 | 0.6823 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0162 | 0.0335 | 0.129 |
Onchocerca volvulus | Cathepsin F homolog | 0.0227 | 0.1053 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0322 | 0.2106 | 0.2106 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Brugia malayi | Cathepsin L-like precursor | 0.0162 | 0.0335 | 0.0335 |
Giardia lamblia | Cathepsin B precursor | 0.0367 | 0.2597 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0322 | 0.2106 | 0.2106 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1038 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1038 | 1 | 1 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0227 | 0.1053 | 0.1053 |
Echinococcus multilocularis | cathepsin b | 0.1038 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.1053 | 0.1053 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Plasmodium vivax | vivapain-2 | 0.0227 | 0.1053 | 1 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0162 | 0.0335 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.0322 | 0.2106 | 0.6823 |
Echinococcus multilocularis | cathepsin b | 0.1038 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0227 | 0.1053 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0227 | 0.1053 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0227 | 0.1053 | 0.0743 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Onchocerca volvulus | Cathepsin L homolog | 0.0227 | 0.1053 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0367 | 0.2597 | 0.2597 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0162 | 0.0336 | 0.0336 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0227 | 0.1053 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0227 | 0.1053 | 0.0743 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0227 | 0.1053 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0227 | 0.1053 | 0.1053 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0367 | 0.2597 | 0.2597 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0227 | 0.1053 | 0.1053 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.1053 | 0.1053 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0227 | 0.1053 | 0.1053 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0227 | 0.1053 | 0.1053 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0227 | 0.1053 | 0.1053 |
Loa Loa (eye worm) | fibroinase | 0.0227 | 0.1053 | 0.0743 |
Echinococcus granulosus | cathepsin l1 | 0.0162 | 0.0335 | 0.0335 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Brugia malayi | cathepsin L-like precursor | 0.0162 | 0.0335 | 0.0335 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0227 | 0.1053 | 0.1053 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0227 | 0.1053 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0227 | 0.1053 | 0.1053 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0162 | 0.0335 | 0.0335 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0367 | 0.2597 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0257 | 0.1389 | 0.1389 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1053 | 0.0743 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Plasmodium vivax | vivapain-2 | 0.0227 | 0.1053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Echinococcus granulosus | cathepsin l1 | 0.0227 | 0.1053 | 0.1053 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0227 | 0.1053 | 0.1053 |
Giardia lamblia | Cathepsin B precursor | 0.0367 | 0.2597 | 0.5 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0227 | 0.1053 | 0.0743 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Loa Loa (eye worm) | hypothetical protein | 0.1038 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.0227 | 0.1053 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0227 | 0.1053 | 0.0743 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0322 | 0.2106 | 0.8111 |
Leishmania major | cathepsin L-like protease | 0.0322 | 0.2106 | 0.6823 |
Toxoplasma gondii | cathepsin B | 0.0367 | 0.2597 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.1053 | 0.1053 |
Echinococcus multilocularis | cysteine protease | 0.0227 | 0.1053 | 0.1053 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0227 | 0.1053 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.1053 | 0.1053 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.1053 | 0.1053 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0162 | 0.0335 | 0.0335 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0227 | 0.1053 | 0.1053 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0227 | 0.1053 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0162 | 0.0335 | 0.129 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0367 | 0.2597 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0227 | 0.1053 | 0.1053 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0367 | 0.2597 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0322 | 0.2106 | 0.2106 |
Brugia malayi | Cathepsin L-like precursor | 0.0162 | 0.0335 | 0.0335 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0227 | 0.1053 | 0.1053 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0322 | 0.2106 | 0.2106 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0367 | 0.2597 | 1 |
Onchocerca volvulus | 0.0227 | 0.1053 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxic concentration (functional) | 0 M | Compound was tested for cytotoxic activity against L1210 leukemia in vitro; IA means inactive | ChEMBL. | 4032424 |
T/C (functional) | = 105 | Inhibitory activity in vivo against P388 leukemia cells in mice at a dose of 50 mg/kg upon intraperitoneal administration | ChEMBL. | 4032424 |
T/C (functional) | = 183 | Inhibitory activity in vivo against P388 leukemia cells in mice at a dose of 100 mg/kg upon intraperitoneal administration | ChEMBL. | 4032424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.