Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Onchocerca volvulus | Putative organic anion transporter | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Trypanosoma cruzi | MFS transporter, putative | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0027 | 0.5 | 0.5 |
Brugia malayi | prostaglandin transporter | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | organic anion transporter | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.5 | 0.5 | |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0027 | 0.5 | 0.5 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0027 | 0.5 | 0.5 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0027 | 0.5 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0027 | 0.5 | 0.5 |
Schistosoma mansoni | organic anion transporter | 0.0027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.5 | 0.5 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 411 uM | Effective dose required to inhibit cell growth against HSV-1 (schooler) | ChEMBL. | No reference |
ED50 (functional) | >= 411 uM | Effective dose required to inhibit cell growth against HSV-2 (186) | ChEMBL. | No reference |
ED50 (functional) | > 411 uM | Effective dose required to inhibit cell growth against VZV (Ellen) | ChEMBL. | No reference |
ED50 (functional) | > 411 uM | Effective dose required to inhibit cell growth against HCMV (AD169) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.