Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | No references |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Death domain containing protein | 0.0864 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 0 | 0.5 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.1319 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 0 | 0.5 |
Brugia malayi | Uncoordinated protein 44 | 0.0864 | 0 | 0.5 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.1319 | 1 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0864 | 0 | 0.5 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.1319 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0864 | 0 | 0.5 |
Onchocerca volvulus | Netrin receptor homolog | 0.0864 | 0 | 0.5 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.1319 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0864 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.2 | Binding affinity against human Dopamine receptor D3 in Chinese hamster ovary cells using [3H]-spiperone. | ChEMBL. | No reference |
Ki (binding) | = -7.3 | Binding affinity against human Dopamine receptor D3 in Chinese hamster ovary cells using [3H]-spiperone. | ChEMBL. | No reference |
Ki (binding) | = -6.5 | Binding affinity against human Dopamine receptor D2 in mouse LtK- cells using [3H]-spiperone. | ChEMBL. | No reference |
Ki (binding) | = -5.9 | Binding affinity against human Dopamine receptor D2 in mouse LtK- cells using [3H]-spiperone. | ChEMBL. | No reference |
Log Ki (binding) | = 5.9 | Binding affinity against human Dopamine receptor D2 in mouse LtK- cells using [3H]-spiperone. | ChEMBL. | No reference |
Log Ki (binding) | = 6.5 | Binding affinity against human Dopamine receptor D2 in mouse LtK- cells using [3H]-spiperone. | ChEMBL. | No reference |
Log Ki (binding) | = 7.3 | Binding affinity against human Dopamine receptor D3 in Chinese hamster ovary cells using [3H]-spiperone. | ChEMBL. | No reference |
Log Ki (binding) | = 8.2 | Binding affinity against human Dopamine receptor D3 in Chinese hamster ovary cells using [3H]-spiperone. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.