Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131775 | All targets in OG5_131775 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 467 aa | 449 aa | 27.6 % |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 451 aa | 393 aa | 25.9 % |
Brugia malayi | excitatory GABA receptor EXP-1A | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 473 aa | 441 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0518 | 0.3444 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0244 | 0.1342 | 0.618 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1319 | 0.4485 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0244 | 0.1342 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0518 | 0.3444 | 0.5 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0082 | 0.0099 | 0.8682 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.1159 | 0.3825 |
Schistosoma mansoni | lipoxygenase | 0.0416 | 0.2661 | 0.2487 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.1373 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0595 | 0.4036 | 0.3894 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.2656 | 1 |
Toxoplasma gondii | MAPEG family protein | 0.1373 | 1 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0154 | 0.0646 | 0.2678 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0099 | 0.0227 | 0.0568 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.1373 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.01 | 0.0231 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0175 | 0.081 | 0.3502 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0595 | 0.4036 | 0.3894 |
Treponema pallidum | hypothetical protein | 0.0084 | 0.0114 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0518 | 0.3444 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.01 | 0.0231 | 0.5 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0244 | 0.1342 | 0.618 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.1373 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0175 | 0.081 | 0.3502 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0099 | 0.0227 | 0.0568 |
Onchocerca volvulus | 0.01 | 0.0231 | 0.5 | |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0241 | 0.1319 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0343 | 0.2101 | 1 |
Onchocerca volvulus | 0.01 | 0.0231 | 0.5 | |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0595 | 0.4036 | 0.3894 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0175 | 0.081 | 0.5229 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1 nM | Binding affinity for Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 | ChEMBL. | 9767648 |
Ki (binding) | = 1 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha5-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 1 nM | Binding affinity for Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 | ChEMBL. | 9767648 |
Ki (binding) | = 1 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha5-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 1 nM | Displacement of [3H]-Ro 15-1788 from Homo sapiens (human) recombinant GABAA alpha5beta3gamma2 receptor expressed in Ltk- cells after 1 hr by liquid scintillation counting | ChEMBL. | No reference |
Ki (binding) | = 15 nM | Binding affinity against alpha3-beta3-gamma2 GABAA/BzR receptor subtype. | ChEMBL. | 9767648 |
Ki (binding) | = 15 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha3-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 15 nM | Binding affinity against alpha3-beta3-gamma2 GABAA/BzR receptor subtype. | ChEMBL. | 9767648 |
Ki (binding) | = 15 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha3-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 15 nM | Displacement of [3H]-Ro 15-1788 from Homo sapiens (human) recombinant GABAA alpha3beta3gamma2 receptor expressed in Ltk- cells after 1 hr by liquid scintillation counting | ChEMBL. | No reference |
Ki (binding) | = 29 nM | Binding affinity of the compound tested against alpha2-beta3-gamma2 GABAA/BzR receptor subtype. | ChEMBL. | 9767648 |
Ki (binding) | = 29 nM | Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha2-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 29 nM | Binding affinity of the compound tested against alpha2-beta3-gamma2 GABAA/BzR receptor subtype. | ChEMBL. | 9767648 |
Ki (binding) | = 29 nM | Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha2-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 29 nM | Displacement of [3H]-Ro 15-1788 from Homo sapiens (human) recombinant GABAA alpha2beta3gamma2 receptor expressed in Ltk- cells after 1 hr by liquid scintillation counting | ChEMBL. | No reference |
Ki (binding) | = 46 nM | Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 | ChEMBL. | 9767648 |
Ki (binding) | = 46 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha6-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 46 nM | Binding affinity against Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2 | ChEMBL. | 9767648 |
Ki (binding) | = 46 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha6-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 46 nM | Displacement of [3H]-Ro 15-4513 from Homo sapiens (human) recombinant GABAA alpha6beta3gamma2 receptor expressed in Ltk- cells after 1 hr by liquid scintillation counting | ChEMBL. | No reference |
Ki (binding) | = 49 nM | Binding affinity against alpha1-beta3-gamma2 GABAA/BzR receptor subtype. | ChEMBL. | 9767648 |
Ki (binding) | = 49 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha1-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 49 nM | Binding affinity against alpha1-beta3-gamma2 GABAA/BzR receptor subtype. | ChEMBL. | 9767648 |
Ki (binding) | = 49 nM | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha1-beta3-gamma2 | ChEMBL. | 10633039 |
Ki (binding) | = 49 nM | Displacement of [3H]-Ro 15-1788 from Homo sapiens (human) recombinant GABAA alpha1beta3gamma2 receptor expressed in Ltk- cells after 1 hr by liquid scintillation counting | ChEMBL. | No reference |
Ratio (binding) | = 49 | It is the ratio of Ki value for alpha1-beta3-gamma2 to that of alpha5-beta3-gamma2 | ChEMBL. | 9767648 |
Ratio (binding) | = 49 | Selectivity ratio of alpha1 beta3 gamma2 GABA A / BzR and alpha5 beta3 gamma2 GABA A / BzR | ChEMBL. | 10633039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.