Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1S subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0237 | 0.1161 | 0.2983 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1471 | 1 | 1 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0237 | 0.1161 | 0.1161 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1471 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0133 | 0.1197 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1108 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1471 | 1 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1471 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.097 | 0.8758 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1471 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0093 | 0.0133 | 0.0133 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0574 | 0.358 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1471 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1471 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0574 | 0.358 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0093 | 0.0133 | 0.1197 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1471 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1471 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0574 | 0.358 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1471 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.1471 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1471 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0574 | 0.358 | 0.358 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0237 | 0.1161 | 0.2983 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0574 | 0.358 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1471 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0574 | 0.358 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Fold reversion (functional) | = 30 | MDR-reversal property tested in vitro on KB-A1 cells, resistance was induced by adriamycin | ChEMBL. | 8831775 |
Fold reversion (functional) | = 270 | MDR-reversal property tested in vitro on P388/VCR-20 cells, resistance was induced by vincristine | ChEMBL. | 8831775 |
Ki (binding) | = 270 nM | Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle | ChEMBL. | 8831775 |
Ki (binding) | = 270 nM | Inhibition of [3H]-D-888 binding to L-type [Ca2+] channel of membranes from rat skeletal muscle | ChEMBL. | 8831775 |
T/V (functional) | = 1.31 | Ratio of survival time of mice treated with VCR (0.25 mg/kg ip)+modulator given at the optimal dose of 100 mg/kg po/survival time of mice treated with VCR alone. | ChEMBL. | 8831775 |
Viability (functional) | = 74 % | Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 74 % | Percent of cell viability of P388/VCR-20 murine leukemia cells remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 132 % | Percent of cell viability of KB-A1 human epidermoid carcinoma remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Viability (functional) | = 132 % | Percent of cell viability of KB-A1 human epidermoid carcinoma remaining after inoculation with the modulator alone | ChEMBL. | 8831775 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.