Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ribonuclease H1 | 0.0043 | 0 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0047 | 0.0151 | 0.0309 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Toxoplasma gondii | ribonuclease HI protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.4894 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0047 | 0.0151 | 0.0309 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0047 | 0.0151 | 0.0309 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0284 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 0.5 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0161 | 0.4894 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0047 | 0.0151 | 0.0309 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0047 | 0.0151 | 0.0309 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0043 | 0 | 0.5 |
Leishmania major | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity rating (functional) | = 10 % | Antihypertensive activity rating in conscious SHR after 2 h post dose at 50 mg/kg (po); Range 10-20% | ChEMBL. | 6827558 |
Activity rating (functional) | = 10 % | Antihypertensive activity in conscious spontaneously hypertensive rats 10 h following 50 mg/kg p.o.; Range 10-20%. | ChEMBL. | 6827558 |
Activity rating (functional) | = 20 % | Antihypertensive activity rating in conscious SHR after 24 h post dose at 50 mg/kg (po); Range 20-30% | ChEMBL. | 6827558 |
Decrease (functional) | = 26 % | Maximum percent decrease in blood pressure in SHR ( hour post dose in parentheses) | ChEMBL. | 6827558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.