Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | 0.0161 | 0.4894 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 1 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0043 | 0 | 0.5 |
Leishmania major | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0047 | 0.0151 | 0.0309 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0047 | 0.0151 | 0.0309 |
Toxoplasma gondii | ribonuclease HI protein | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0043 | 0 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0047 | 0.0151 | 0.0309 |
Echinococcus granulosus | ribonuclease H1 | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0047 | 0.0151 | 0.0309 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0284 | 1 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0047 | 0.0151 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0161 | 0.4894 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity rating (functional) | = 0 % | Antihypertensive activity in conscious spontaneously hypertensive rats 24 h following 50 mg/kg p.o.; No significant reduction. | ChEMBL. | 6827558 |
Activity rating (functional) | = 10 % | Antihypertensive activity in conscious spontaneously hypertensive rats 10 h following 50 mg/kg p.o.; Range 10-20%. | ChEMBL. | 6827558 |
Activity rating (functional) | = 20 % | Antihypertensive activity rating in conscious SHR after 2 h post dose at 50 mg/kg (po); Range 20-30% | ChEMBL. | 6827558 |
Decrease (functional) | = 26 % | Maximum percent decrease in blood pressure in SHR ( hour post dose in parentheses) | ChEMBL. | 6827558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.