Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Growth rate (functional) | = 9 uM | Antiproliferative activity in L1210 Murine Leukemia in vitro expressed as Growth rate in the presence of compound | ChEMBL. | 7562946 |
IC50 (functional) | = 0.003 uM | antiviral activity as 50% inhibitory concentration againstVZV | ChEMBL. | 7562946 |
IC50 (functional) | = 0.0037 uM | Antiviral activity as 50% inhibitory concentration against HSV-1 | ChEMBL. | 7562946 |
IC50 (binding) | = 0.02 uM | antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatant | ChEMBL. | 7562946 |
IC50 (functional) | = 0.025 uM | antiviral activity in Human cytomegalovirus by plaque assay (HCMV) | ChEMBL. | 7562946 |
IC50 (functional) | = 0.03 uM | Antiviral activity as 50% inhibitory concentration against HSV-1 | ChEMBL. | 7562946 |
IC50 (functional) | = 0.03 uM | Antiviral activity as 50% inhibitory concentration against HSV-2 | ChEMBL. | 7562946 |
IC50 (functional) | = 0.13 uM | Cytotoxicity in human foreskin fibroblast (HFF) stationary by MTT assay | ChEMBL. | 7562946 |
IC50 (functional) | = 0.16 uM | Cytotoxicity in human foreskin fibroblast (HFF) stationary by MTT assay | ChEMBL. | 7562946 |
IC50 (functional) | = 0.193 uM | cytotoxicity in CEM-SS cells by [3H]-Thd uptake | ChEMBL. | 7562946 |
IC50 (functional) | = 0.4 uM | Visual cytotoxicity scored on CEM cells at time of HCMV plaque enumeration | ChEMBL. | 7562946 |
IC50 (functional) | = 0.4 uM | cytotoxicity in CEM-SS cells by visual inspection | ChEMBL. | 7562946 |
IC50 (functional) | = 0.47 uM | Antiviral activity in Herpes simplex virus-1 assayed by ELISA in quadruplicate wells | ChEMBL. | 7562946 |
IC50 (functional) | = 1.9 uM | cell growth inhibition was determined in KB cells in quadruplicate assays | ChEMBL. | 7562946 |
IC50 (functional) | = 3.2 uM | antiproliferative activity in L1210 Murine Leukemia in vitro expressed as concentration required to decrease growth rate to 50% of control | ChEMBL. | 7562946 |
IC50 (functional) | = 5.5 uM | Visual cytotoxicity scored on HFF cells at time of HCMV plaque enumeration | ChEMBL. | 7562946 |
IC50 (functional) | = 6.7 uM | Cytotoxicity in human foreskin fibroblast (HFF) stationary cells as neutral red uptake | ChEMBL. | 7562946 |
IC90 (functional) | = 0.075 uM | antiviral activity in Human cytomegalovirus by plaque assay given as yield | ChEMBL. | 7562946 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.