Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0158 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0158 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0158 | 0.5 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0158 | 0.5 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0158 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0158 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0158 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0158 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0158 | 0.5 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0158 | 0.5 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0158 | 0.5 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0158 | 0.5 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0158 | 0.5 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0158 | 0.5 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0158 | 0.5 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0158 | 0.5 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Leishmania major | beta tubulin | 0.0158 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cell cycle analysis (functional) | 0 | Effect of the compound on the cell cycle progression using P388 cells at 4.0 ug/mL for 24 hr; No effect | ChEMBL. | 10866386 |
IC50 (functional) | = 7.2 ug ml-1 | In vitro antiproliferative activity measured against colon 38 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 7.2 ug ml-1 | In vitro antiproliferative activity measured against colon 38 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 8.2 ug ml-1 | In vitro antiproliferative activity measured against P388 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 8.200000000000001 ug ml-1 | In vitro antiproliferative activity measured against P388 cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 15 ug ml-1 | In vitro antiproliferative activity measured against KB cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
IC50 (functional) | = 15 ug ml-1 | In vitro antiproliferative activity measured against KB cancer cell line using MTT colorimetric assay | ChEMBL. | 10866386 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10866386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.