Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0164 | 0.5 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0164 | 0.5 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0164 | 0.5 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0164 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 320 ug ml-1 | Minimum concentration required to inhibit Enterococcus faecalis ATCC29212 | ChEMBL. | 12954069 |
MIC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Staphylococcus aureus ATCC25923 | ChEMBL. | 12954069 |
MIC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
MIC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853 | ChEMBL. | 12954069 |
MIC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
MLC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Enterococcus faecalis ATCC29212 | ChEMBL. | 12954069 |
MLC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Staphylococcus aureus ATCC25923 | ChEMBL. | 12954069 |
MLC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
MLC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Pseudomonas aeruginosa ATCC27853 | ChEMBL. | 12954069 |
MLC (functional) | = 3200 ug ml-1 | Minimum concentration required to inhibit Escherichia coli ATCC25922 | ChEMBL. | 12954069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.