Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 2.1849 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 2.1324 | 0.9759 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1111 | 0.0479 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 2.1324 | 0.9759 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1111 | 0.0479 | 0.0491 |
Loa Loa (eye worm) | thymidylate synthase | 2.1324 | 0.9759 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0307 | 0.011 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 2.1849 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 1.0311 | 0.4703 | 0.4552 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0307 | 0.011 | 0.0113 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 2.1849 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 1.0311 | 0.4703 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 2.1849 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 1.0311 | 0.4703 | 0.4819 |
Brugia malayi | thymidylate synthase | 2.1324 | 0.9759 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 2.1324 | 0.9759 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 2.1324 | 0.9759 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1111 | 0.0479 | 0.0491 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0307 | 0.011 | 0.0113 |
Echinococcus granulosus | thymidylate synthase | 2.1324 | 0.9759 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 2.1324 | 0.9759 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 2.1849 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1111 | 0.0479 | 0.0491 |
Onchocerca volvulus | 2.1324 | 0.9759 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against S. pneumoniae ATCC 6303 Ery-S | ChEMBL. | 11708916 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against S. pyogenes EES 61 Ery-S | ChEMBL. | 11708916 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration against S. pneumoniae 5649 efflux | ChEMBL. | 11708916 |
MIC (functional) | = 6.2 ug ml-1 | Minimum inhibitory concentration against S. aureus ATCC 6538PEry-S | ChEMBL. | 11708916 |
MIC (functional) | = 6.2 ug ml-1 | Minimum inhibitory concentration against S. aureus A 5177 MLSB-i | ChEMBL. | 11708916 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration against S. pyogenes PIU2548 efflux | ChEMBL. | 11708916 |
MIC (functional) | = 64 ug ml-1 | Minimum inhibitory concentration against H. influenzae DILL Amp-R | ChEMBL. | 11708916 |
MIC (functional) | > 100 ug ml-1 | Minimum inhibitory concentration against S. aureus A 5278 MLSB-c | ChEMBL. | 11708916 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against S. pneumoniae 5737 MLSB | ChEMBL. | 11708916 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against S. pyogenes 930MLSB | ChEMBL. | 11708916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.