Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0875 | 0.6033 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1427 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1427 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0156 | 0.0878 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1427 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0329 | 0.2116 | 0.2116 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0155 | 0.0866 | 0.0866 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0875 | 0.6033 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0329 | 0.2116 | 0.1357 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0875 | 0.6033 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0329 | 0.2116 | 0.2116 |
Schistosoma mansoni | dihydrofolate reductase | 0.1427 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0329 | 0.2116 | 0.2116 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0875 | 0.6033 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1427 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0156 | 0.0878 | 0.0878 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0155 | 0.0866 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1427 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1427 | 1 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0155 | 0.0866 | 0.0866 |
Onchocerca volvulus | 0.0329 | 0.2116 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0875 | 0.6033 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0875 | 0.6033 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1427 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1427 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 93.6 nM | Affinity towards anti-beta-endorphin MAb(Clone 3-E7) using [3H]-[Leu5]-enkephalin as labeled ligand | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.