Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 1 precursor | 0.0185 | 0.0973 | 0.0973 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0185 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4255 | 0.4255 |
Echinococcus granulosus | glutamate receptor 2 | 0.0214 | 0.1398 | 0.3834 |
Onchocerca volvulus | Putative nachr subunit | 0.0119 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0797 | 1 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0214 | 0.1398 | 0.3834 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0214 | 0.1398 | 0.3834 |
Schistosoma mansoni | glutamate receptor NMDA | 0.03 | 0.2671 | 0.7325 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0214 | 0.1398 | 0.3834 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Echinococcus granulosus | nmda type glutamate receptor | 0.023 | 0.1645 | 0.451 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0185 | 0.0973 | 0.2669 |
Echinococcus granulosus | glutamate receptor 2 | 0.013 | 0.017 | 0.0466 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Schistosoma mansoni | glutamate receptor kainate | 0.0185 | 0.0973 | 0.2669 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0185 | 0.0973 | 0.0973 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0214 | 0.1398 | 0.3834 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0214 | 0.1398 | 0.3834 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0185 | 0.0973 | 0.2669 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0214 | 0.1398 | 0.3834 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0214 | 0.1398 | 0.3834 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Echinococcus multilocularis | glutamate receptor 2 | 0.013 | 0.017 | 0.0466 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0214 | 0.1398 | 0.3834 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Echinococcus multilocularis | glutamate receptor 2 | 0.0185 | 0.0973 | 0.2669 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0366 | 0.3646 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0214 | 0.1398 | 0.3834 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.023 | 0.1645 | 0.451 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0797 | 1 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0185 | 0.0973 | 0.2669 |
Schistosoma mansoni | glutamate receptor kainate | 0.0185 | 0.0973 | 0.2669 |
Schistosoma mansoni | glutamate receptor kainate | 0.0185 | 0.0973 | 0.2669 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0366 | 0.3646 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0797 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0366 | 0.3646 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0144 | 0.0372 | 0.1019 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0185 | 0.0973 | 0.0973 |
Onchocerca volvulus | 0.0119 | 0 | 0.5 | |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0797 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | ND 0 uM | Inhibitory activity against HIV-1 Wild Type in MT-4 cells; not determined. | ChEMBL. | 10514285 |
ED50 (functional) | = 0.008 uM | Inhibition of wild type HIV-1 in MT-4 cell culture (human T cell line) | ChEMBL. | 10514285 |
ED50 (functional) | = 0.008 uM | Inhibition of wild type HIV-1 in MT-4 cell culture (human T cell line) | ChEMBL. | 10514285 |
ED50 (functional) | = 0.04 uM | Inhibitory activity against HIV-1 Ile 100 mutant in MT-4 cells. | ChEMBL. | 10514285 |
ED50 (functional) | = 0.04 uM | Inhibitory activity against HIV-1 Ile 100 mutant in MT-4 cells. | ChEMBL. | 10514285 |
ED50 (functional) | = 0.104 uM | Inhibitory activity against HIV-1 Asn 103 mutant in MT-4 cells. | ChEMBL. | 10514285 |
ED50 (functional) | = 0.104 uM | Inhibitory activity against HIV-1 Asn 103 mutant in MT-4 cells. | ChEMBL. | 10514285 |
ED50 (functional) | = 0.23 uM | Inhibitory activity against HIV-1 Cys 181 mutant in MT-4 cells. | ChEMBL. | 10514285 |
ED50 (functional) | = 0.23 uM | Inhibitory activity against HIV-1 Cys 181 mutant in MT-4 cells. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.0053 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Wild Type Reverse transcriptase using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.0053 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Wild Type Reverse transcriptase using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.013 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Ile 100 mutant using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.013 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Ile 100 mutant using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.016 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Cys181 mutant using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.016 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Cys181 mutant using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.098 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Asn103 mutant using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
IC50 (binding) | = 0.098 uM | HIV-1 reverse transcriptase inhibitory activity of the compound against Asn103 mutant using (poly)rC600*(oligo)dGT as template primer. | ChEMBL. | 10514285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.