Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0162 | 1 | 0.5 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0143 | 0.4498 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0158 | 0.886 | 0.7927 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0158 | 0.886 | 0.7927 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0162 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0162 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0162 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0162 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0162 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0162 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0162 | 1 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0162 | 1 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0131 | 0.0693 | 0.0693 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0162 | 1 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0158 | 0.8898 | 0.7997 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0162 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0162 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0162 | 1 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0158 | 0.886 | 0.886 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0162 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0143 | 0.4498 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0162 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0162 | 1 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0162 | 1 | 0.5 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0143 | 0.4498 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0162 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0162 | 1 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0158 | 0.8898 | 0.7997 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0162 | 1 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0162 | 1 | 1 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0143 | 0.4498 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.00000012 M | Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhibition constant was determined after preincubating the enzyme and inhibitor | ChEMBL. | 6142952 |
Ki (binding) | = 0.00001176 M | Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and inhibitor | ChEMBL. | 6142952 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.