Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Onchocerca volvulus | 0.0101 | 0.0877 | 0.1482 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0088 | 0.0164 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0535 | 0.5382 | 0.5382 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0535 | 0.5382 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0535 | 0.5382 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0101 | 0.0877 | 0.0877 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0093 | 0.0173 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0093 | 0.0173 |
Schistosoma mansoni | lamin | 0.0026 | 0.0093 | 0.0173 |
Echinococcus multilocularis | enteropeptidase | 0.0101 | 0.0877 | 0.0877 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0093 | 0.0173 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0384 | 0.0713 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | Trypsin family protein | 0.0101 | 0.0877 | 0.1629 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0101 | 0.0877 | 0.0877 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0206 | 0.0383 |
Brugia malayi | Trypsin family protein | 0.0101 | 0.0877 | 0.1629 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0323 | 0.3184 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Onchocerca volvulus | 0.0101 | 0.0877 | 0.1482 | |
Brugia malayi | Protein kinase domain containing protein | 0.0535 | 0.5382 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0093 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0384 | 0.0713 |
Echinococcus granulosus | lamin | 0.0026 | 0.0093 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Onchocerca volvulus | 0.0101 | 0.0877 | 0.1482 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0206 | 0.0383 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0323 | 0.3184 | 0.5916 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0093 | 0.0093 |
Onchocerca volvulus | 0.0101 | 0.0877 | 0.1482 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0093 | 0.0173 |
Echinococcus granulosus | Mastin | 0.0101 | 0.0877 | 0.1629 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0323 | 0.3184 | 0.5916 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0093 | 0.0173 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0323 | 0.3184 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0101 | 0.0877 | 0.0877 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0093 | 0.0173 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | lamin | 0.0026 | 0.0093 | 0.0173 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | Kringle domain containing protein | 0.0535 | 0.5382 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | trypsin family protein | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0206 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0323 | 0.3184 | 0.5916 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Toxoplasma gondii | kringle domain-containing protein | 0.0535 | 0.5382 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0323 | 0.3184 | 0.5143 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | hypothetical protein | 0.0535 | 0.5382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | hypothetical protein | 0.0535 | 0.5382 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0323 | 0.3184 | 1 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0323 | 0.3184 | 0.5916 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | Trypsin family protein | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0535 | 0.5382 | 1 |
Onchocerca volvulus | 0.0535 | 0.5382 | 1 | |
Onchocerca volvulus | 0.0101 | 0.0877 | 0.1482 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0093 | 0.0173 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Leishmania major | hypothetical protein, conserved | 0.0535 | 0.5382 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0323 | 0.3184 | 0.5916 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0323 | 0.3184 | 0.5143 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0384 | 0.0713 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0101 | 0.0877 | 0.0877 |
Mycobacterium ulcerans | hypothetical protein | 0.0101 | 0.0877 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Onchocerca volvulus | 0.0101 | 0.0877 | 0.1482 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0101 | 0.0877 | 0.1629 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0384 | 0.0713 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0323 | 0.3184 | 0.3184 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0101 | 0.0877 | 0.1629 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0323 | 0.3184 | 0.5916 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0323 | 0.3184 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0535 | 0.5382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0877 | 0.1629 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0101 | 0.0877 | 0.0877 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0101 | 0.0877 | 0.1629 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0535 | 0.5382 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | ~ 100 uM | Inhibition of human fibroblast stromelysin | ChEMBL. | 8277511 |
IC50 (binding) | > 100 uM | Inhibition of human fibroblast collagenase | ChEMBL. | 8277511 |
IC50 (binding) | ~ 100 uM | Inhibition of human fibroblast stromelysin | ChEMBL. | 8277511 |
IC50 (binding) | > 100 uM | Inhibition of human fibroblast collagenase | ChEMBL. | 8277511 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.