Detailed information for compound 233281

Basic information

Technical information
  • TDR Targets ID: 233281
  • Name: N-[2-(5-cyclopentylpentanoylamino)ethyl]-6-hy droxy-2,5,7,8-tetramethyl-3,4-dihydrochromene -2-carboxamide
  • MW: 444.607 | Formula: C26H40N2O4
  • H donors: 3 H acceptors: 3 LogP: 5.48 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCCNC(=O)C1(C)CCc2c(O1)c(C)c(c(c2C)O)C)CCCCC1CCCC1
  • InChi: 1S/C26H40N2O4/c1-17-18(2)24-21(19(3)23(17)30)13-14-26(4,32-24)25(31)28-16-15-27-22(29)12-8-7-11-20-9-5-6-10-20/h20,30H,5-16H2,1-4H3,(H,27,29)(H,28,31)
  • InChiKey: DICRZYWLTDTDNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(5-cyclopentylpentanoylamino)ethyl]-6-hydroxy-2,5,7,8-tetramethyl-chromane-2-carboxamide
  • N-[2-[(5-cyclopentyl-1-oxopentyl)amino]ethyl]-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-carboxamide
  • N-[2-(5-cyclopentylpentanoylamino)ethyl]-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxamide
  • N-[2-(5-cyclopentylpentanoylamino)ethyl]-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide
  • N-[2-[(5-cyclopentyl-1-oxopentyl)amino]ethyl]-6-hydroxy-2,5,7,8-tetramethyl-2-chromancarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (5HT) receptor 0.0325 0.0194 0.0307
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0325 0.0194 0.0307
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0325 0.0194 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0325 0.0194 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0325 0.0194 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0325 0.0194 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis sex peptide receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni opsin-like receptor 0.0325 0.0194 0.0307
Echinococcus granulosus 7tm_1 domain containing protein 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Echinococcus multilocularis neuropeptide Y receptor 0.0325 0.0194 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni hypothetical protein 0.0325 0.0194 0.0307
Schistosoma mansoni histamine h1 receptor 0.0325 0.0194 0.0307
Brugia malayi putative neuropeptide receptor NPR1 0.0325 0.0194 1
Echinococcus granulosus neuropeptides capa receptor 0.0325 0.0194 1
Brugia malayi AKH receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis neuropeptide s receptor 0.0325 0.0194 1
Schistosoma mansoni adenoreceptor 0.0325 0.0194 0.0307
Schistosoma mansoni biogenic amine (5HT) receptor 0.0325 0.0194 0.0307
Echinococcus multilocularis allatostatin A receptor 0.0325 0.0194 1
Echinococcus granulosus allatostatin A receptor 0.0325 0.0194 1
Echinococcus granulosus neuropeptide Y receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0089 0.4583
Echinococcus granulosus neuropeptide receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Echinococcus multilocularis neuropeptide receptor A26 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0325 0.0194 0.0307
Echinococcus multilocularis somatostatin receptor 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0325 0.0194 0.0307
Brugia malayi G-protein coupled receptor 0.0325 0.0194 1
Loa Loa (eye worm) neuropeptide F receptor 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0325 0.0194 1
Echinococcus multilocularis fmrfamide receptor 0.0325 0.0194 1
Schistosoma mansoni opsin-like receptor 0.0325 0.0194 0.0307
Brugia malayi hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni neuropeptide F-like receptor 0.0325 0.0194 0.0307
Echinococcus multilocularis g protein coupled receptor 0.0325 0.0194 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0325 0.0194 1
Echinococcus granulosus neuropeptide receptor A26 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Echinococcus multilocularis G protein coupled receptor 139 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0034 0.1437
Brugia malayi GnHR receptor homolog 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0325 0.0194 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Brugia malayi putative neuropeptide receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Brugia malayi larval opioid receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Brugia malayi G protein-coupled receptor 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0325 0.0194 0.0307
Echinococcus granulosus g protein coupled receptor 0.0325 0.0194 1
Echinococcus granulosus serotonin transporter 0.0174 0.0089 0.439
Schistosoma mansoni neuropeptide receptor 0.0325 0.0194 0.0307
Brugia malayi G-protein coupled receptor 0.0325 0.0194 1
Brugia malayi Dopamine receptor protein 2 0.0325 0.0194 1
Echinococcus granulosus tm gpcr rhodopsin 0.0325 0.0194 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0325 0.0194 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0325 0.0194 1
Brugia malayi neuropeptide F receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Brugia malayi Serotonin receptor 0.0325 0.0194 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0325 0.0194 1
Loa Loa (eye worm) TYRA-2 protein 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0325 0.0194 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0034 0.1437
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0325 0.0194 0.0307
Echinococcus granulosus 7TM GPCR rhodopsin 0.0325 0.0194 1
Echinococcus granulosus fmrfamide receptor 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0325 0.0194 0.0307
Echinococcus granulosus serotonin receptor 0.0325 0.0194 1
Schistosoma mansoni hypothetical protein 0.0325 0.0194 0.0307
Brugia malayi neuropeptide F receptor 0.0325 0.0194 1
Echinococcus granulosus somatostatin receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0325 0.0194 0.0307
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0325 0.0194 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0325 0.0194 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0174 0.0089 0.0135
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0325 0.0194 1
Echinococcus multilocularis fmrfamide receptor 0.0325 0.0194 1
Echinococcus multilocularis g-protein coupled receptor 0.0325 0.0194 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0174 0.0089 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0325 0.0194 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0325 0.0194 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0174 0.0089 0.0135
Echinococcus granulosus peptide allatostatin:somatostatin 0.0325 0.0194 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0325 0.0194 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Brugia malayi Dopamine receptor protein 1 0.0325 0.0194 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0089 0.4583
Echinococcus granulosus g protein coupled receptor 0.0325 0.0194 1
Mycobacterium ulcerans histidinol dehydrogenase 1.4413 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni neuropeptide F-like receptor 0.0325 0.0194 0.0307
Onchocerca volvulus 0.0325 0.0194 1
Schistosoma mansoni biogenic amine receptor 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0325 0.0194 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Echinococcus multilocularis neuropeptides capa receptor 0.0325 0.0194 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0325 0.0194 1
Echinococcus granulosus neuropeptides capa receptor 0.0325 0.0194 1
Schistosoma mansoni hypothetical protein 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.0089 0.4583
Onchocerca volvulus Neuropeptide F receptor homolog 0.0325 0.0194 1
Schistosoma mansoni amine GPCR 0.0325 0.0194 0.0307
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Schistosoma mansoni neuropeptide receptor 0.0325 0.0194 0.0307
Loa Loa (eye worm) serotonin transporter b 0.0174 0.0089 0.4583
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0325 0.0194 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0325 0.0194 0.0307
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Schistosoma mansoni biogenic amine receptor 0.0325 0.0194 0.0307
Echinococcus granulosus g protein coupled receptor 0.0325 0.0194 1
Echinococcus multilocularis g protein coupled receptor 0.0325 0.0194 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0325 0.0194 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0325 0.0194 1
Brugia malayi ORL1-like opioid receptor 0.0325 0.0194 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Brugia malayi Melatonin receptor type 1A 0.0325 0.0194 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0325 0.0194 1
Echinococcus granulosus neuropeptide s receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus dro:myosuppressin receptor 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0174 0.0089 0.4583
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis serotonin receptor 0.0325 0.0194 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0174 0.0089 0.2856
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Onchocerca volvulus 0.0174 0.0089 0.439
Echinococcus multilocularis neuropeptides capa receptor 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Echinococcus multilocularis neuropeptide Y receptor 0.0325 0.0194 1
Loa Loa (eye worm) G-protein coupled receptor 0.0325 0.0194 1
Echinococcus granulosus orexin receptor type 2 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0114 0.0047 0.2417
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0325 0.0194 1
Brugia malayi sulfakinin receptor protein 0.0325 0.0194 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Echinococcus multilocularis neuropeptide receptor 0.0325 0.0194 1
Echinococcus granulosus sex peptide receptor 0.0325 0.0194 1
Echinococcus granulosus tm gpcr rhodopsin 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Schistosoma mansoni amine GPCR 0.0325 0.0194 0.0307
Brugia malayi RE15519p 0.0325 0.0194 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0325 0.0194 0.0307
Echinococcus granulosus G protein coupled receptor 139 0.0325 0.0194 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0194 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0325 0.0194 1
Echinococcus granulosus g-protein coupled receptor 0.0325 0.0194 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0325 0.0194 1
Loa Loa (eye worm) norepinephrine transporter 0.0174 0.0089 0.4583
Schistosoma mansoni hypothetical protein 0.0325 0.0194 0.0307
Brugia malayi hypothetical protein 0.0325 0.0194 1
Echinococcus multilocularis orexin receptor type 2 0.0325 0.0194 1
Echinococcus multilocularis serotonin receptor 0.0325 0.0194 1
Brugia malayi follicle stimulating hormone receptor 0.0325 0.0194 1
Echinococcus multilocularis neuropeptide receptor 0.0325 0.0194 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0325 0.0194 0.0307
Brugia malayi hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni myosin xvIII 0.0325 0.0194 0.0307
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0325 0.0194 1
Echinococcus granulosus tm gpcr rhodopsin 0.0325 0.0194 1
Echinococcus granulosus neuropeptide receptor 0.0325 0.0194 1
Echinococcus multilocularis g protein coupled receptor 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus neuropeptide Y receptor 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0194 0.0307
Schistosoma mansoni opsin-like receptor 0.0325 0.0194 0.0307
Schistosoma mansoni biogenic amine receptor 0.0325 0.0194 0.0307
Brugia malayi Dopamine receptor 0.0325 0.0194 1
Schistosoma mansoni amine GPCR 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0325 0.0194 1
Schistosoma mansoni neuropeptide receptor 0.0325 0.0194 0.0307
Loa Loa (eye worm) melatonin receptor type 1A 0.0325 0.0194 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0325 0.0194 1
Onchocerca volvulus 0.0325 0.0194 1
Loa Loa (eye worm) G-protein coupled receptor 0.0325 0.0194 1
Loa Loa (eye worm) neuropeptide F receptor 0.0325 0.0194 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0194 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0325 0.0194 0.0307
Schistosoma mansoni neuropeptide f receptor 76f 0.0325 0.0194 0.0307
Onchocerca volvulus 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni amine GPCR 0.0325 0.0194 0.0307
Schistosoma mansoni amine GPCR 0.8813 0.6102 1
Brugia malayi hypothetical protein 0.0325 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0325 0.0194 0.0307
Echinococcus multilocularis serotonin transporter 0.0174 0.0089 0.439
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0325 0.0194 1
Brugia malayi Serotonin receptor 0.0325 0.0194 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0325 0.0194 1
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 1.4413 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Schistosoma mansoni neuropeptide receptor 0.0325 0.0194 0.0307
Loa Loa (eye worm) hypothetical protein 0.0325 0.0194 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0325 0.0194 1

Activities

Activity type Activity value Assay description Source Reference
Arrhythmia score (functional) = 6.98 Effect on in vitro myocardial electrical activity (arrhythmia score) at 5 microM ChEMBL. 11708933
cLogP = 5.96 The compound was evaluated for lipophilicity ChEMBL. 11708933
IC50 (functional) = 0.158 mM The compound was evaluated for the interaction with 0.2 mM of the stable free radical DPPH ChEMBL. 11708933
IC50 (functional) = 0.73 uM Inhibition of in vitro peroxidation (LP) of rat Hepatic microsomal membrane lipid ChEMBL. 11708933
MDA content (functional) = 1.41 uM (g of tissue)-1 Effect of compound on in vitro accumulation of MDA content in heart at 5 microM ChEMBL. 11708933

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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