Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0393 | 0.5178 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0393 | 0.5178 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0393 | 0.5178 | 0.5 |
Schistosoma mansoni | integrin alpha | 0.0307 | 0.3448 | 0.6659 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0393 | 0.5178 | 0.5 |
Echinococcus multilocularis | integrin alpha 3 | 0.0236 | 0.1989 | 0.2977 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0393 | 0.5178 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0236 | 0.1989 | 0.2977 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0393 | 0.5178 | 0.7749 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0393 | 0.5178 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0393 | 0.5178 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0393 | 0.5178 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0393 | 0.5178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.2105 | 0.156 |
Schistosoma mansoni | integrin beta subunit | 0.0371 | 0.4737 | 0.9147 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0393 | 0.5178 | 0.7749 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.5178 | 0.4845 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0393 | 0.5178 | 0.7749 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0393 | 0.5178 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.0467 | 0.6682 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0393 | 0.5178 | 0.7749 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0393 | 0.5178 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0474 | 0.6833 | 0.6614 |
Plasmodium vivax | RNA helicase-1, putative | 0.0393 | 0.5178 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0393 | 0.5178 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0393 | 0.5178 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0467 | 0.6682 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0393 | 0.5178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1926 | 0.1368 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0307 | 0.3448 | 0.1886 |
Loa Loa (eye worm) | integrin beta-2 | 0.063 | 1 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0143 | 0.0095 | 0.0183 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0393 | 0.5178 | 0.4028 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0393 | 0.5178 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0393 | 0.5178 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0143 | 0.0095 | 0.0183 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0393 | 0.5178 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC50 (functional) | = 79 uM | Lowest concentration to reduce viral effect by 50% or more against Rhinovirus (RV)-1A | ChEMBL. | 3005578 |
MIC50 (functional) | = 157 uM | Lowest concentration to reduce viral effect by 50% or more against Rhinovirus (RV)-2 | ChEMBL. | 3005578 |
MIC50 (functional) | = 157 uM | Lowest concentration to reduce viral effect by 50% or more against coxsackie virus A21 | ChEMBL. | 3005578 |
Toxicity (ADMET) | = 157 uM | Cytotoxicity concentration in HeLa cells | ChEMBL. | 3005578 |
Toxicity (ADMET) | = 157 uM | Cytotoxicity concentration in HeLa cells | ChEMBL. | 3005578 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.