Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1729 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0117 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1729 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1729 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0117 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0117 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0117 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0117 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0117 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0716 | 0.4073 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.1758 | 1 |
Onchocerca volvulus | 0.0117 | 0 | 0.5 | |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0117 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0117 | 0 | 0.5 |
Onchocerca volvulus | 0.0117 | 0 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1729 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0592 | 0.3364 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1729 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1729 | 1 | 1 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0232 | 0.0716 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0117 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1729 | 1 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0117 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0117 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0117 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.1729 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Hypocotyl length (functional) | = 0.5 cm | Inhibitory activity on cress growth at a concentration of 5 microM | ChEMBL. | 10091696 |
Hypocotyl length (functional) | = 0.75 cm | Inhibitory activity on cress growth at a concentration of 1 microM | ChEMBL. | 10091696 |
Hypocotyl length (functional) | = 1.25 cm | Inhibitory activity on cress growth at a concentration of 0.5 microM | ChEMBL. | 10091696 |
Hypocotyl length (functional) | ~ 2 cm | Inhibitory activity on cress growth at a concentration of 0.05 microM | ChEMBL. | 10091696 |
Hypocotyl length (functional) | ~ 2.25 cm | Inhibitory activity on cress growth at a concentration of 0.1 microM | ChEMBL. | 10091696 |
Rice stem length (functional) | ~ 2.7 cm | Compound was tested for its activity in rice stem elongation test at a concentration of 1 microM. Stem length was measured after 7 days of transplantation | ChEMBL. | 10091696 |
Rice stem length (functional) | ~ 2.7 cm | Compound was tested for its activity in rice stem elongation test at a concentration of 1 microM. Stem length was measured after 7 days of transplantation | ChEMBL. | 10091696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.